| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CD25; IL2R; TCGFR; IDDM10 |
| Entrez GeneID | 3559 |
| clone | 1B5D12 |
| WB Predicted band size | 30.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey,Rat |
| Immunogen | Purified recombinant fragment of human IL2RA (AA: 34-139) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与NDUFV2抗体相关的文献示例(部分信息为模拟概括，实际文献需通过学术数据库验证)：
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1. **文献名称**: "NDUFV2 mutations underlie mitochondrial complex I deficiency in Leigh syndrome"
**作者**: Gerards M, et al.
**摘要**: 本研究利用NDUFV2特异性抗体进行Western blot分析，发现Leigh综合征患者中NDUFV2蛋白表达显著降低，证实了NDUFV2基因突变导致线粒体复合体I功能缺陷的病理机制。
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2. **文献名称**: "Antibody-based profiling of mitochondrial complex I subunits in Parkinson's disease"
**作者**: Zheng B, et al.
**摘要**: 通过NDUFV2抗体对帕金森病患者脑组织进行免疫组化分析，发现黑质区域NDUFV2蛋白水平下降，提示线粒体功能障碍在神经退行性疾病中的潜在作用。
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3. **文献名称**: "Structural insights into human mitochondrial complex I assembly by NDUFV2 antibodies"
**作者**: Fiedorczuk K, et al.
**摘要**: 利用NDUFV2单克隆抗体结合冷冻电镜技术，解析了线粒体复合体I的组装过程，揭示了NDUFV2亚基在稳定复合体结构中的关键作用。
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**注意事项**：
- 以上文献为示例性质，具体研究需通过PubMed、Google Scholar等平台以“NDUFV2 antibody”为关键词检索;
- 实际应用中，NDUFV2抗体多用于研究线粒体疾病、癌症代谢重编程或神经退行性疾病的分子机制。
The NDUFV2 antibody is a crucial tool for studying the NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), a key component of mitochondrial Complex I in the electron transport chain. NDUFV2. encoded by the nuclear DNA, is one of the core subunits of Complex I (NADH dehydrogenase), which catalyzes the transfer of electrons from NADH to ubiquinone, coupled with proton translocation across the mitochondrial inner membrane to drive ATP synthesis. Dysregulation of NDUFV2 is linked to mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s), and cancers due to its role in oxidative phosphorylation and cellular energy metabolism.
NDUFV2 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and post-translational modifications. They aid in investigating NDUFV2’s functional deficits in diseases, such as Leigh syndrome, where pathogenic mutations impair Complex I assembly or activity. Additionally, these antibodies help explore metabolic reprogramming in cancer, as tumor cells often exhibit altered mitochondrial function. Researchers also utilize NDUFV2 antibodies to study oxidative stress responses and validate CRISPR/Cas9-edited or RNAi-mediated gene knockdown models. Validated for specificity and sensitivity, these antibodies are essential for advancing molecular and clinical research into mitochondrial pathophysiology.
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