| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NB; DAN; NO3; DAND1; D1S1733E |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NBL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NBL1抗体的3篇模拟参考文献示例(内容为假设性概括，仅供参考)：
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1. **文献名称**: "NBL1/SAG Expression in Neuroblastoma: A Tumor Suppressor Role via Wnt Signaling"
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性NBL1抗体检测神经母细胞瘤组织中的蛋白表达，发现NBL1在晚期肿瘤中显著下调，并通过抑制Wnt/β-catenin通路抑制肿瘤生长，提示其作为潜在治疗靶点。
2. **文献名称**: "Development of a Monoclonal Antibody for NBL1 and Its Diagnostic Utility in Colorectal Cancer"
**作者**: Li X, et al.
**摘要**: 文章报道了一种新型抗NBL1单克隆抗体的开发，并通过免疫组化验证其在结直肠癌中的表达。结果显示，NBL1低表达与患者不良预后相关，该抗体可作为诊断标志物。
3. **文献名称**: "NBL1 Antibody-Based Screening Reveals Epigenetic Silencing in Glioblastoma"
**作者**: Chen R, et al.
**摘要**: 通过NBL1抗体检测胶质母细胞瘤样本，发现NBL1启动子高甲基化导致其表达沉默，恢复表达可增强肿瘤细胞对化疗的敏感性，为表观遗传治疗提供依据。
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注：以上文献为示例，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
The NBL1 antibody targets the protein product of the neuroblastoma suppressor of tumorigenicity 1 (NBL1) gene, also known as DAN family BMP antagonist member 1 (DAN). NBL1 belongs to the DAN family of secreted glycoproteins, which act as bone morphogenetic protein (BMP) antagonists by binding to BMP ligands and inhibiting their interaction with receptors. This regulation is critical for balancing BMP-mediated signaling pathways involved in embryonic development, tissue homeostasis, and cell differentiation.
NBL1 is implicated as a potential tumor suppressor, with studies showing its downregulation in various cancers, including neuroblastoma, glioblastoma, and colorectal cancer. Reduced NBL1 expression correlates with tumor progression, metastasis, and poor prognosis, suggesting its role in restraining oncogenic pathways.
Antibodies against NBL1 are widely used in research to detect protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate NBL1's functional mechanisms, including its interaction with BMPs and other signaling molecules. Some studies also explore its diagnostic or therapeutic potential in cancers. However, variability in NBL1 expression across tissues and cancer types underscores the complexity of its biological roles, necessitating further investigation. Most NBL1 antibodies are raised in rabbits or mice using immunogenic peptide sequences, with validation in specific experimental models.
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