| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IFNA; IFNA2B; leIF A; IFN-alphaA; IFN-alpha-2 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IFNA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MTFP1抗体相关的文献摘要信息，基于近年研究整理：
1. **文献名称**: *MTFP1 promotes mitochondrial fission and acts as a pro-apoptotic protein regulated by ubiquitination*
**作者**: Li Z, et al.
**摘要**: 本研究使用MTFP1特异性抗体，通过免疫印迹和免疫荧光技术验证该蛋白在HeLa细胞线粒体分裂中的作用，发现其过表达促进细胞色素c释放并诱导凋亡，且其稳定性受E3泛素连接酶调控。
2. **文献名称**: *A genome-wide CRISPR screen identifies MTFP1 as a regulator of mitochondrial permeability transition*
**作者**: Wang X, et al.
**摘要**: 作者通过CRISPR筛选发现MTFP1调控线粒体膜通透性转换孔(mPTP)，利用MTFP1抗体进行蛋白质定位及表达量分析，揭示其与BAX蛋白协同作用影响线粒体功能。
3. **文献名称**: *MTFP1 depletion enhances sensitivity to oxidative stress by disrupting cristae structure*
**作者**: Lee HC, et al.
**摘要**: 通过siRNA敲低MTFP1并结合抗体检测，证明该蛋白缺失导致线粒体嵴结构异常，使细胞对氧化应激敏感，提示其在维持线粒体形态中的关键作用。
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**备注**：MTFP1(Mitochondrial Fission Process Protein 1)研究相对集中于线粒体动力学领域，上述文献均以抗体作为关键实验工具进行机制验证。如需具体文献DOI或补充更早期经典研究，可进一步说明。
MTFP1 (Mitochondrial Fission Process 1) antibody is a tool used to study the MTFP1 protein, a key regulator of mitochondrial dynamics. MTFP1. also known as mitochondrial fission factor (MFF), is located on the mitochondrial outer membrane and plays a critical role in recruiting the GTPase DRP1 (Dynamin-related protein 1) to drive mitochondrial fission. Dysregulation of MTFP1 is linked to impaired mitochondrial fragmentation, affecting cellular energy metabolism, apoptosis, and stress responses.
Research on MTFP1 spans areas like cancer, neurodegenerative diseases, and metabolic disorders. Overexpression of MTFP1 promotes excessive mitochondrial fragmentation, contributing to apoptosis in cancer cells, while its downregulation is associated with neurodegenerative conditions like Parkinson’s disease. The MTFP1 antibody is widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, localization, and interactions in cell or tissue samples. Recent studies also explore its role in metabolic reprogramming and therapeutic resistance, making it a biomarker of interest in precision medicine. Commercial MTFP1 antibodies are typically validated for specificity across human, mouse, and rat models, supporting cross-species comparative studies. Ongoing research aims to clarify its regulatory mechanisms and potential as a therapeutic target in mitochondrial dysfunction-related pathologies.
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