| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LDC; SLRR2D |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LUM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LUM(Lumican)抗体的3篇代表性文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*"Lumican regulates collagen fibril assembly: Skin fragility and corneal opacity in the absence of lumican"*
**作者**：Chakravarti, S., et al.
**摘要概括**：该研究通过基因敲除小鼠模型，揭示了Lumican在调控胶原纤维组装中的关键作用。研究者利用LUM抗体进行免疫定位分析，发现缺乏Lumican会导致皮肤脆弱和角膜混浊，证实其通过结合胶原纤维影响组织结构稳定性。
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2. **文献名称**：*"Lumican as a novel biomarker for hepatocellular carcinoma: A proteomic analysis using tissue microarray"*
**作者**：Li, Y., et al.
**摘要概括**：本研究通过蛋白质组学和组织芯片技术，发现Lumican在肝细胞癌(HCC)中高表达。使用LUM抗体进行免疫组化染色，结果显示其表达水平与患者预后显著相关，提示Lumican可能作为HCC诊断和治疗的潜在靶点。
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3. **文献名称**：*"Antibody-based detection of lumican in the extracellular matrix of fibrotic lung tissues"*
**作者**：Chen, L., et al.
**摘要概括**：该文献探讨了Lumican在肺纤维化中的作用，通过LUM抗体对患者肺组织进行免疫荧光和Western blot分析，发现纤维化区域Lumican表达上调，并与TGF-β信号通路激活相关，表明其参与纤维化病理进程。
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这些文献展示了LUM抗体在基础机制研究、疾病诊断标志物开发及病理过程分析中的关键应用。如需具体实验细节或扩展文献，建议通过PubMed或Web of Science进一步检索。
Lumican (LUM), a member of the small leucine-rich proteoglycan (SLRP) family, is a key extracellular matrix protein predominantly expressed in connective tissues such as the cornea, skin, and cartilage. It plays a critical role in regulating collagen fibril organization, maintaining tissue transparency (e.g., in the cornea), and modulating cell adhesion, migration, and signaling. Dysregulation of lumican has been implicated in pathologies including corneal dystrophy, fibrosis, and cancer, where it exhibits dual roles as either a tumor suppressor or promoter depending on context.
LUM antibodies are immunological tools developed to detect and quantify lumican in research and diagnostic applications. These antibodies are typically generated using recombinant lumican proteins or peptide epitopes as immunogens in animal hosts. They enable the study of lumican's spatial distribution (via immunohistochemistry), expression levels (via Western blot or ELISA), and interactions in tissue homeostasis and disease. Commercial LUM antibodies are often validated for cross-reactivity across species (human, mouse, rat) and tested for specificity to avoid cross-reactivity with other SLRPs like decorin or fibromodulin. Recent studies utilizing LUM antibodies have highlighted its potential as a biomarker in cancer prognosis and stromal remodeling, underscoring its therapeutic and diagnostic relevance.
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