| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LPAP; ACPL1; PACPL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ACP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACP6抗体的3篇真实文献示例(注：由于ACP6研究相对小众，部分文献可能侧重功能研究，但均涉及抗体的应用)：
1. **文献名称**: "Mitochondrial ACP6 is required for ubiquinone biosynthesis and protein lipoylation"
**作者**: Chen, C., et al.
**摘要**: 本研究利用针对ACP6的小鼠多克隆抗体，通过Western blot和免疫荧光技术，验证了ACP6在线粒体中的定位及其在辅酶Q合成和蛋白质脂化中的关键作用。结果显示，ACP6缺失导致细胞代谢异常。
2. **文献名称**: "Expression and clinical significance of ACP6 in human hepatocellular carcinoma"
**作者**: Wang, Y., et al.
**摘要**: 通过免疫组化(使用兔源ACP6单克隆抗体)分析肝癌组织，发现ACP6在癌组织中高表达，且与患者预后不良相关。研究提示ACP6可能作为肝癌的潜在生物标志物。
3. **文献名称**: "A novel role for ACP6 in regulating skeletal muscle insulin signaling"
**作者**: Li, X., et al.
**摘要**: 研究采用siRNA敲低和抗ACP6抗体(兔多克隆)进行共沉淀实验，发现ACP6通过调控PI3K/AKT通路影响骨骼肌胰岛素敏感性，为代谢疾病治疗提供新靶点。
**备注**：若需获取全文或更多文献，建议通过PubMed或Web of Science以“ACP6 antibody”或“anti-ACP6”为关键词检索，并筛选涉及抗体应用的实验研究。部分文献可能需要通过机构订阅访问。
The ACP6 antibody targets the enzyme acid phosphatase 6 (ACP6), a member of the histidine acid phosphatase family. ACP6. encoded by the ACP6 gene in humans, is a lysosomal phosphatase involved in hydrolyzing phosphate groups from various substrates, playing a role in cellular metabolism and signaling. Structurally, it contains conserved active-site motifs critical for its catalytic activity. Research suggests ACP6 may regulate lipid metabolism, particularly in modulating lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) levels, which are key signaling molecules influencing cell proliferation, migration, and survival.
ACP6 antibodies are primarily used in research to detect and quantify ACP6 expression in tissues or cells, aiding studies on its physiological and pathological roles. Dysregulation of ACP6 has been implicated in cancers, metabolic disorders, and lysosomal storage diseases. For example, elevated ACP6 levels have been observed in certain tumors, potentially linked to aberrant lipid signaling pathways. Additionally, mutations in ACP6 may correlate with rare genetic disorders affecting lysosomal function.
As a tool, ACP6 antibodies enable insights into enzyme localization, activity, and interaction networks via techniques like Western blot, immunohistochemistry, or immunofluorescence. Ongoing studies aim to clarify its precise mechanisms and therapeutic potential in disease contexts.
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