Rabbit Polyclonal KIF2A Antibody

The KIF2A antibody is a crucial tool for studying the kinesin family member 2A (KIF2A), a microtubule-depolymerizing motor protein belonging to the kinesin-13 family. KIF2A plays essential roles in regulating microtubule dynamics during mitosis, neuronal development, and intracellular transport. It is involved in processes such as spindle assembly, chromosome segregation, and axonal pruning by selectively destabilizing microtubules. Researchers use KIF2A antibodies primarily to detect and quantify KIF2A expression in various biological samples, investigate its subcellular localization, and explore its functional interactions in cellular pathways. These antibodies are typically generated using recombinant KIF2A proteins or specific peptide fragments as immunogens, with common hosts including rabbits and mice. Validation methods like Western blotting, immunofluorescence, and immunohistochemistry ensure specificity, often showing bands at ~85 kDa (full-length protein) or detecting splice variants. Dysregulation of KIF2A has been linked to cancers (e.g., breast, lung), where its overexpression may correlate with tumor progression and metastasis, making it a potential biomarker or therapeutic target. Additionally, KIF2A mutations are associated with neurodevelopmental disorders like malformations of cortical development, highlighting its importance in brain development. The antibody thus serves as a key reagent in both basic research and clinical studies bridging cytoskeletal dynamics to disease mechanisms.