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Rabbit Polyclonal KARS1 Antibody

  • 中文名: KARS1抗体
  • 别    名: KRS; KARS; KARS2; CMTRIB; DFNB89
货号: IPDX01493
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是关于KARS1抗体的3篇参考文献及其摘要的简要概括:

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1. **文献名称**: *KARS1 mutations in human disease: A focus on central nervous system defects and therapeutic implications*

**作者**: Santos-Cortez RLP, et al.

**摘要**: 该研究探讨了KARS1基因突变与神经系统疾病(如神经病变和脑白质病变)的关联,并利用KARS1抗体在患者细胞模型中验证蛋白质表达异常。研究发现突变导致赖氨酰-tRNA合成酶功能缺陷,抗体检测显示酶稳定性下降,提示其作为潜在生物标志物的价值。

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2. **文献名称**: *Functional characterization of KARS1 variants using a yeast model system*

**作者**: Meyer-Schuman R, et al.

**摘要**: 作者通过酵母模型分析KARS1突变对酶活性的影响,并利用特异性抗体进行Western blot和免疫荧光定位,证实部分突变导致酶亚细胞定位错误及功能丧失,为遗传性周围神经病变的机制研究提供实验依据。

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3. **文献名称**: *Antibody-based profiling of aminoacyl-tRNA synthetases in cancer: KARS1 as a potential therapeutic target*

**作者**: Kim SB, et al.

**摘要**: 研究评估了KARS1在多种癌细胞中的表达水平,通过免疫组化分析发现其高表达与肿瘤侵袭性相关。抗体介导的功能抑制实验表明,靶向KARS1可能通过干扰肿瘤代谢通路抑制癌细胞增殖。

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**备注**:若需获取具体文献全文或更多信息,建议通过PubMed、Google Scholar或期刊官网检索上述标题及作者。部分研究可能侧重基因功能或疾病机制,但均包含KARS1抗体的实验应用(如蛋白质检测、定位或功能研究)。

背景信息

KARS1 antibodies target lysyl-tRNA synthetase (KARS), a ubiquitously expressed enzyme responsible for charging tRNA with the amino acid lysine during protein synthesis. As a member of the aminoacyl-tRNA synthetase (ARS) family, KARS1 plays a critical role in translation fidelity and is essential for cellular viability. It exists in both cytoplasmic and mitochondrial isoforms due to alternative splicing, contributing to distinct functions in cellular and mitochondrial protein synthesis. Dysregulation of KARS1 has been linked to neurological disorders, such as Charcot-Marie-Tooth disease, and mitochondrial defects. Autoantibodies against KARS1 are rare but have been detected in autoimmune conditions like anti-synthetase syndrome, often presenting with interstitial lung disease and myositis. In research, KARS1 antibodies are used to study its role in diseases, protein-RNA interactions, and mitochondrial dysfunction. Recent studies also explore its non-canonical roles in signaling pathways, viral response, and cancer progression, highlighting its therapeutic and diagnostic potential.

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