| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ITGB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGB2抗体的3篇示例文献(注：文献为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Targeting ITGB2 in Leukocyte Adhesion Deficiency: A Monoclonal Antibody Therapy Approach*"
**作者**: Smith, J.R. et al.
**摘要**: 研究开发了一种靶向ITGB2的单克隆抗体，可恢复白细胞粘附功能缺陷患者的细胞迁移能力，为先天性免疫缺陷疾病提供了潜在治疗策略。
2. **文献名称**: *"Anti-ITGB2 Antibody Attenuates Neutrophil-Mediated Inflammation in Sepsis Models*"
**作者**: Li, X. & Wang, H.
**摘要**: 通过动物模型证明，阻断ITGB2的抗体可抑制中性粒细胞过度浸润，降低脓毒症炎症反应，揭示了其在急性炎症性疾病中的治疗潜力。
3. **文献名称**: *"Structural Insights into ITGB2 Epitopes for Antibody Binding in Cancer Immunotherapy*"
**作者**: Gonzalez, A. et al.
**摘要**: 利用冷冻电镜解析了ITGB2与其治疗性抗体的复合物结构，阐明了关键结合表位，为设计靶向ITGB2的肿瘤免疫治疗药物提供结构基础。
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**提示**：实际研究中建议通过PubMed、Google Scholar等平台搜索关键词“ITGB2 antibody”或“CD18 antibody”，并筛选近年(如2020-2023年)的高影响力论文，关注其抗体应用场景(如炎症、免疫调控或癌症)。
ITGB2 antibody targets the β2 subunit (CD18) of integrins, a family of transmembrane adhesion receptors critical for immune cell function. Integrin β2 pairs with distinct α subunits (CD11a, CD11b, CD11c, CD11d) to form heterodimers like LFA-1 (αLβ2), Mac-1 (αMβ2), and others. These receptors mediate leukocyte adhesion, migration, and signaling during inflammatory responses and immune surveillance. ITGB2 is predominantly expressed on leukocytes, including neutrophils, lymphocytes, and macrophages. Its dysfunction is linked to leukocyte adhesion deficiency type 1 (LAD-1), a rare immunodeficiency disorder characterized by recurrent infections and impaired wound healing due to defective leukocyte extravasation.
ITGB2 antibodies are widely used in research to study integrin-mediated processes, such as immune cell trafficking, phagocytosis, and immunological synapse formation. They serve as tools in flow cytometry, immunohistochemistry, and functional assays to block or detect β2 integrin activity. Therapeutic antibodies targeting β2 integrins have been explored for modulating inflammatory diseases (e.g., rheumatoid arthritis, ischemia-reperfusion injury) but face challenges due to immunosuppressive side effects. Recent studies also implicate β2 integrins in cancer metastasis and neutrophil extracellular trap (NET) formation, expanding their relevance in oncology and autoimmune research. These antibodies remain pivotal in dissecting the structural and functional complexity of integrins in health and disease.
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