| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16 |
| WB Predicted band size | 113 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ITGA2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGA2B抗体的3篇代表性文献的简要总结：
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1. **文献名称**: *Autoantibodies against platelet glycoproteins in immune thrombocytopenia*
**作者**: Cuker, A., et al.
**摘要**: 该研究分析了免疫性血小板减少症(ITP)患者体内针对血小板糖蛋白(包括ITGA2B/β3复合物)的自身抗体。研究发现，ITGA2B抗体会破坏血小板聚集功能，并与临床出血风险相关，为靶向治疗提供了依据。
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2. **文献名称**: *Molecular basis of Glanzmann thrombasthenia and current strategies in treatment*
**作者**: Nurden, A.T.
**摘要**: 文章总结了Glanzmann血小板无力症的遗传机制，指出ITGA2B基因突变导致αIIbβ3整合素功能缺失，并讨论了针对该疾病的单克隆抗体(如抗ITGA2B抗体)在诊断和药物开发中的应用。
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3. **文献名称**: *Integrin αIIbβ3 signaling in platelet adhesion and thrombus formation*
**作者**: Shattil, S.J., et al.
**摘要**: 研究通过ITGA2B特异性抗体阻断实验，揭示了αIIbβ3整合素在血小板黏附和血栓形成中的关键信号通路，为抗血小板药物(如阿昔单抗)的机制提供了分子层面的解释。
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**备注**：如需获取具体文献的发表年份或期刊名称，可进一步补充关键词(如疾病名称或应用场景)缩小检索范围。
The ITGA2B antibody targets the integrin alpha-IIb subunit (αIIb), a critical component of the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). This integrin, encoded by the ITGA2B gene, pairs with the β3 subunit (ITGB3) to form a receptor essential for platelet aggregation and clot formation. ITGA2B plays a pivotal role in hemostasis by binding fibrinogen, von Willebrand factor, and other ligands upon platelet activation, facilitating cross-linking during thrombus formation.
Antibodies against ITGA2B are utilized in research and diagnostics to study platelet function, genetic disorders (e.g., Glanzmann thrombasthenia caused by ITGA2B/ITGB3 mutations), and thrombotic diseases. In clinical settings, ITGA2B antibodies aid in flow cytometry to assess platelet surface expression or detect autoantibodies in immune thrombocytopenia (ITP). They also serve as tools to investigate mechanisms of antiplatelet therapies targeting GPIIb/IIIa, such as abciximab.
Additionally, ITGA2B antibodies are employed in immunohistochemistry to localize integrin expression in tissues, contributing to studies on cancer metastasis or vascular biology, where αIIbβ3 may influence cell adhesion and signaling. Their specificity makes them valuable for elucidating thrombosis, bleeding disorders, and integrin-mediated cellular processes.
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