| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | 16G2; Gugu; IRL685 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FETUB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FETUB抗体的3篇参考文献，涵盖其功能研究及抗体应用：
---
1. **文献名称**: *"Fetuin-B regulates vascular plaque calcification in chronic kidney disease"*
**作者**: Smith A, et al.
**摘要**: 该研究探讨了FETUB在慢性肾病血管钙化中的作用，利用特异性抗体检测其在斑块中的表达，发现其通过抑制钙沉积调节病理过程。
---
2. **文献名称**: *"Anti-FETUB monoclonal antibody development for early ovarian failure diagnosis"*
**作者**: Zhang L, et al.
**摘要**: 研究团队开发了一种高灵敏度的抗FETUB单克隆抗体，用于卵巢早衰的血清标志物检测，验证了其在临床样本中的诊断潜力。
---
3. **文献名称**: *"Fetuin-B deficiency alters sperm motility via antibody-mediated protein interaction analysis"*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫共沉淀(使用FETUB抗体)和基因敲除模型，揭示了FETUB缺失导致精子运动缺陷的分子机制，强调其在男性生育中的关键作用。
---
(注：以上文献为示例，实际引用时需以真实文献为准。建议通过PubMed或Google Scholar以关键词“Fetuin B antibody”或“FETUB immunoassay”检索近期论文。)
FETUB (Fetuin-B) is a liver-secreted glycoprotein belonging to the cystatin superfamily, first identified as a homolog of fetuin-A (alpha-2-HS-glycoprotein). Primarily expressed in hepatocytes, it shares structural similarities with protease inhibitors but exhibits distinct functional roles. FETUB gained attention for its involvement in metabolic regulation and reproductive biology. Studies link it to lipid metabolism, insulin resistance, and ovarian follicle development, with elevated levels observed in conditions like NAFLD (non-alcoholic fatty liver disease) and PCOS (polycystic ovary syndrome). Notably, FETUB inhibits metalloproteinases such as ovastacin, playing a critical role in zona pellucida hardening during fertilization.
FETUB antibodies, typically monoclonal or polyclonal, are essential tools for detecting this protein in immunoassays (ELISA, Western blot) and tissue localization studies. Their development accelerated after the discovery of FETUB's dual role in metabolic disorders and reproductive processes. Recent research focuses on FETUB's potential as a biomarker for metabolic syndromes and its therapeutic implications. Commercial antibodies often target specific epitopes in its cystatin-like domains or unique regions differentiating it from fetuin-A. Validation remains crucial due to FETUB's structural homology with other cystatin family members. Ongoing studies explore its interactions with adipokines and inflammatory pathways, expanding its relevance in metabolic and fertility research.
×
