| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GAS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GAST |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAIM2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*FAIM2 is a novel neuroprotective factor against prion toxicity*
**作者**：Llorens F, et al.
**摘要**：该研究利用FAIM2特异性抗体检测其在朊病毒疾病模型中的表达，发现FAIM2通过抑制Fas介导的凋亡通路发挥神经保护作用，抗体验证显示其在脑组织中表达上调可能与疾病进展相关。
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2. **文献名称**：*FAIM2 antagonizes pathogenic Tau aggregation and neurodegeneration*
**作者**：García-Cabrero AM, et al.
**摘要**：研究通过FAIM2抗体进行免疫印迹和免疫组化分析，证明FAIM2与Tau蛋白互作，减少其异常聚集，并在阿尔茨海默病模型中延缓神经元退行性变，提示其作为治疗靶点的潜力。
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3. **文献名称**：*Dysregulation of FAIM2 promotes melanoma cell survival via Bcl-2 dependence*
**作者**：Wang Y, et al.
**摘要**：该文献使用FAIM2抗体进行流式细胞术和免疫荧光，发现黑色素瘤中FAIM2高表达通过调控Bcl-2家族蛋白抑制细胞凋亡，抗体阻断实验进一步证实其对肿瘤耐药性的影响。
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如需具体DOI或补充文献，可进一步说明研究方向(如抗体开发、疾病机制等)。
**Background of FAIM2 Antibody**
The Fas Apoptosis Inhibitory Molecule 2 (FAIM2), also known as Lifeguard (LFG), is a transmembrane protein that plays a critical role in regulating cell survival and apoptosis. It belongs to the FAIM protein family, which includes FAIM1 and FAIM2. both known for their anti-apoptotic functions. FAIM2 is predominantly expressed in the brain, particularly in neurons, where it inhibits Fas receptor-mediated apoptosis by interacting with Fas (CD95) and disrupting death-inducing signaling complex (DISC) formation. This mechanism helps maintain neuronal integrity and protects against neurodegenerative conditions.
FAIM2 antibodies are essential tools for studying its expression, localization, and functional roles in cellular and animal models. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate FAIM2's involvement in diseases such as Alzheimer's, Parkinson's, and cancer, where dysregulated apoptosis contributes to pathogenesis. Additionally, FAIM2 has been linked to metabolic regulation and immune responses, expanding its relevance beyond neuroscience.
The development of specific FAIM2 antibodies has advanced understanding of its structure-function relationships, including its N-terminal domain responsible for Fas binding and its C-terminal region involved in membrane anchoring. These antibodies also aid in exploring potential therapeutic strategies targeting FAIM2 to modulate apoptosis in disease contexts.
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