| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TOSO; FAIM3 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FCMR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与FCMR(Fcμ受体)抗体相关的文献概览：
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1. **文献名称**：*Fcμ receptor as a novel B cell receptor for IgM*
**作者**：Honjo, K. et al.
**摘要**：该研究首次鉴定了FcμR(FCMR)是B细胞表面特异性结合IgM的受体，证明其通过调控B细胞受体(BCR)信号通路参与B细胞存活与自身免疫耐受的维持，为自身免疫疾病机制提供了新视角。
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2. **文献名称**：*FcμR interacts and cooperates with the B cell receptor to promote B cell survival*
**作者**：Ouchida, R. et al.
**摘要**：本文揭示了FcμR与BCR在B细胞表面形成复合物，通过激活PI3K-Akt信号通路增强B细胞存活，实验表明FcμR缺陷小鼠的B细胞凋亡增加，提示其在适应性免疫中的关键作用。
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3. **文献名称**：*The role of FcμR in regulating humoral immune responses and autoimmunity*
**作者**：Kubagawa, H. et al.
**摘要**：综述性研究总结了FcμR在体液免疫中的双重功能：既能通过结合IgM-抗原复合物增强抗原呈递，又能清除自身反应性B细胞以防止自身抗体产生，为治疗自身免疫疾病提供了潜在靶点。
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如需具体文献年份或期刊信息，可进一步补充关键词或研究背景!
**Background of FCMR Antibody**
The Fc mu receptor (FCMR), also known as TOSO or FAIM3. is a transmembrane protein primarily expressed on B lymphocytes and a subset of T cells. It binds to the Fc region of immunoglobulin M (IgM), playing a critical role in regulating B-cell survival, immune complex clearance, and maintaining peripheral tolerance. FCMR is implicated in modulating B-cell receptor (BCR) signaling, where it can either enhance or inhibit apoptosis depending on cellular context, thus influencing immune responses and autoimmune disease progression.
Research highlights FCMR's dual functionality: it promotes B-cell activation and antibody production under certain conditions, while also suppressing excessive immune activation to prevent autoimmunity. Dysregulation of FCMR has been linked to autoimmune disorders (e.g., systemic lupus erythematosus), chronic lymphocytic leukemia (CLL), and infections. FCMR-targeting antibodies are valuable tools for studying its ligand interactions, signaling pathways, and therapeutic potential. Recent studies explore blocking FCMR to counteract pathogenic IgM-mediated inflammation or leveraging it to enhance B-cell targeting in malignancies. However, its complex biology necessitates further research to clarify mechanistic nuances and optimize therapeutic applications.
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