| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ET2; PPET2 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human EDN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EDN2抗体的3篇参考文献示例(注：文献为虚构示例，仅供参考格式)：
1. **文献名称**：*"EDN2 Antibody-Based Detection of Endothelin-2 in Ovarian Cancer Tissues"*
**作者**：Smith A, et al.
**摘要**：研究利用特异性EDN2抗体通过免疫组化技术，揭示了EDN2在卵巢癌组织中的高表达，并发现其表达水平与肿瘤血管生成及患者预后不良显著相关。
2. **文献名称**：*"Development of a Novel Monoclonal Antibody for EDN2 with High Specificity in Immunoassays"*
**作者**：Johnson B, et al.
**摘要**：报道了一种新型EDN2单克隆抗体的开发与验证，该抗体在ELISA和Western blot中表现出高灵敏度和特异性，为EDN2的定量检测提供了可靠工具。
3. **文献名称**：*"Neutralizing EDN2 Antibody Attenuates Pulmonary Hypertension in Experimental Models"*
**作者**：Lee C, et al.
**摘要**：通过动物模型证明，使用EDN2中和抗体可显著抑制内皮素信号通路，减轻肺动脉高压的病理特征，提示其作为潜在治疗策略的可能性。
4. **文献名称**：*"EDN2 Antibody Reveals Its Role in Inflammatory Bowel Disease Pathogenesis"*
**作者**：Garcia D, et al.
**摘要**：利用EDN2抗体研究发现，EDN2在肠道炎症组织中异常上调，通过阻断其活性可减少促炎因子释放，为炎症性肠病的机制研究提供了新方向。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed。)
The eosinophil-derived neurotoxin 2 (EDN2), also known as ribonuclease A family member 3 (RNASE3), is a cytotoxic protein primarily secreted by activated eosinophils, a type of immune cell implicated in allergic responses and antiparasitic defense. Structurally, EDN2 belongs to the RNase A superfamily and shares homology with eosinophil-derived neurotoxin (EDN/RNASE2), exhibiting ribonuclease activity that contributes to its pathogen-clearing and immunomodulatory functions. It is stored in eosinophil granules and released upon stimulation, playing roles in host defense, inflammation, and tissue remodeling. EDN2 has been linked to conditions such as asthma, allergic diseases, and helminth infections, where eosinophils are pathologically activated.
Antibodies targeting EDN2 are critical tools for studying its expression, localization, and function in both physiological and disease contexts. They enable detection of EDN2 in biological samples (e.g., serum, tissues) via techniques like ELISA, immunohistochemistry, and Western blot. Such antibodies also aid in exploring EDN2’s dual role as a mediator of immune defense and a contributor to inflammatory tissue damage. Research using EDN2-specific antibodies has provided insights into eosinophil activation pathways and potential therapeutic strategies for eosinophil-driven disorders. Commercial EDN2 antibodies are typically developed in rabbits or mice, validated for specificity, and widely used in biomedical research to dissect eosinophil biology and related pathologies.
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