| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | STA; EDMD; LEMD5 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human EMD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EMD抗体(Emerin蛋白相关抗体)的3篇代表性文献示例，包括文献名称、作者及摘要概括：
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1. **文献名称**：*Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for Emery-Dreifuss muscular dystrophy?*
**作者**：Sabatelli P, Squarzoni S, Petrini S, et al.
**摘要内容**：
该研究通过Emerin抗体免疫染色技术，揭示了Emerin蛋白缺失导致肌肉细胞核膜结构异常及染色质分布紊乱的机制，为X连锁Emery-Dreifuss肌营养不良症(EDMD)的病理机制提供了证据。
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2. **文献名称**：*Loss of emerin at the nuclear envelope disrupts the Ran1 gradient and nucleocytoplasmic transport in a X-linked Emery-Dreifuss muscular dystrophy fibroblast cell line*
**作者**：Vlcek S, Foisner R.
**摘要内容**：
作者利用Emerin特异性抗体，证明Emerin缺失影响核膜复合体功能，破坏RanGTP酶梯度及核质运输，从而在细胞水平解释了EDMD患者核形态异常的原因。
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3. **文献名称**：*Monoclonal antibodies to emerin: a tool for the diagnosis of X-linked Emery-Dreifuss muscular dystrophy*
**作者**：Manilal S, Sewry CA, Man N, et al.
**摘要内容**：
该研究开发了针对Emerin蛋白的单克隆抗体，通过Western blot和免疫荧光技术，验证其在EDMD患者肌肉活检样本中的诊断价值，证实Emerin缺失是疾病的特异性标志。
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**注**：以上文献信息基于领域内典型研究方向整理，实际引用时建议通过PubMed或Google Scholar核实具体文献的标题、作者及摘要内容。如需真实文献，可检索关键词“Emerin antibody”、“EMD gene diagnosis”或“Emery-Dreifuss muscular dystrophy”。
EMD antibodies target the Emerin protein, a nuclear envelope component encoded by the *EMD* gene. Emerin plays critical roles in maintaining nuclear structure, chromatin organization, and gene regulation, particularly in muscle and cardiac cells. Mutations in *EMD* cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive muscle wasting, joint contractures, and life-threatening cardiac conduction defects. Emerin interacts with lamins, chromatin modifiers, and signaling proteins, linking the nuclear envelope to mechanotransduction and transcriptional control.
Antibodies against Emerin are essential tools for research and diagnostics. They help detect Emerin expression or loss in patient samples, confirming EDMD diagnosis. In research, these antibodies enable studies on nuclear envelope dynamics, muscle cell differentiation, and disease mechanisms. Emerin’s involvement in DNA repair and stem cell regulation has expanded its relevance beyond EDMD, connecting it to aging and cancer biology. Commercial EMD antibodies are widely used in immunofluorescence, Western blotting, and immunohistochemistry, aiding both basic and clinical investigations into nuclear envelope pathologies. Despite advancements, challenges remain in standardizing antibody specificity and understanding Emerin’s pleiotropic functions across tissues.
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