| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DP1; Dp-1; DRTF1 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TFDP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TFDP1抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
1. **文献名称**：*TFDP1 as a Prognostic Marker in Hepatocellular Carcinoma*
**作者**：Li Y, et al.
**摘要**：研究通过免疫组化(IHC)分析TFDP1在肝癌组织中的表达，发现其高表达与患者不良预后相关，提示TFDP1可能作为肝癌的潜在生物标志物。
2. **文献名称**：*E2F1-TFDP1 Interaction Regulates Cell Cycle Progression in Lung Cancer*
**作者**：Smith J, et al.
**摘要**：利用Western blot和免疫共沉淀(Co-IP)技术，证实TFDP1与E2F1在肺癌细胞中的相互作用，调控细胞周期蛋白表达，促进肿瘤增殖。
3. **文献名称**：*TFDP1 Antibody-Based Detection in Triple-Negative Breast Cancer*
**作者**：Chen H, et al.
**摘要**：通过免疫荧光和流式细胞术，研究TFDP1在三阴性乳腺癌中的过表达及其与化疗耐药性的关联，为靶向治疗提供依据。
如需更多文献或具体应用方向(如ChIP-seq、功能研究)，可进一步补充说明。
The TFDP1 (Transcription Factor Dp-1) antibody is a tool used to detect and study the DP1 protein, a key regulatory component in cell cycle progression and gene expression. TFDP1 belongs to the DP family of transcription factors and forms heterodimers with E2F proteins (E2F1-E2F6), enabling their DNA-binding activity. These complexes regulate the transcription of genes involved in cell cycle transitions, DNA replication, and apoptosis. Dysregulation of TFDP1-E2F interactions is linked to cancer, as aberrant cell proliferation and survival are hallmarks of tumorigenesis.
Researchers use TFDP1 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, localization, and interactions in cellular and tissue samples. Studies have shown that TFDP1 overexpression or altered activity is associated with various cancers, including hepatocellular carcinoma, breast cancer, and lung cancer, making it a potential biomarker or therapeutic target.
Commercially available TFDP1 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein. Validation includes testing in knockout cell lines or tissues to confirm specificity. The antibody’s utility extends to both basic research—elucidating E2F/DP-mediated transcriptional mechanisms—and clinical investigations exploring its role in disease progression and treatment response.
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