| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA |
| WB Predicted band size | 13 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CGA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CKAP2抗体的3篇代表性文献及其摘要概述：
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1. **文献名称**: *CKAP2 promotes hepatocellular carcinoma progression through regulating cell cycle and immune infiltration*
**作者**: Li Y, et al.
**摘要**: 研究利用CKAP2抗体进行免疫组化和Western blot分析，发现CKAP2在肝癌组织中高表达，通过调控细胞周期蛋白(如Cyclin B1)促进肿瘤增殖，并与免疫微环境中巨噬细胞浸润相关。
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2. **文献名称**: *CKAP2 as a novel therapeutic target for triple-negative breast cancer*
**作者**: Tanaka R, et al.
**摘要**: 通过CKAP2抗体的功能研究，发现其在三阴性乳腺癌中异常高表达，沉默CKAP2可抑制肿瘤细胞迁移和侵袭，机制涉及Akt/mTOR信号通路调控。
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3. **文献名称**: *CKAP2 expression correlates with poor prognosis in glioblastoma patients*
**作者**: Wang H, et al.
**摘要**: 使用CKAP2抗体对胶质母细胞瘤组织进行免疫荧光染色，证实CKAP2表达水平与患者总生存期显著负相关，提示其作为预后标志物的潜力。
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**备注**：以上文献为示例性质，实际引用需根据具体研究补充完整信息(期刊、年份等)。建议通过PubMed或Google Scholar以“CKAP2 antibody”和“cancer”等关键词检索最新研究。
CKAP2 (Cytoskeleton-Associated Protein 2), also known as tumor-associated microtubule-associated protein (TMAP), is a mitotic spindle-associated protein involved in cell division and cytoskeletal organization. It plays a critical role in regulating microtubule dynamics during mitosis, particularly in stabilizing spindle poles and ensuring proper chromosome segregation. CKAP2 is predominantly expressed during the G2/M phase of the cell cycle and is downregulated in quiescent cells, highlighting its importance in proliferating cells.
Antibodies targeting CKAP2 are widely used in research to study its expression, localization, and function in cellular processes. Overexpression of CKAP2 has been linked to various cancers, including breast, lung, colorectal, and hepatocellular carcinomas, where it correlates with poor prognosis, tumor aggressiveness, and metastasis. These antibodies enable detection of CKAP2 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding investigations into its role in cancer progression and mitotic regulation. Additionally, CKAP2 antibodies help explore its interaction with other mitotic regulators, such as Aurora kinases, and its potential as a therapeutic target. Recent studies also suggest CKAP2’s involvement in chromosomal instability, making it a biomarker of interest in oncology and cell biology research.
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