| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HRAS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ATP1B2抗体的代表性文献示例(注：具体文献信息需根据实际研究核实)：
1. **文献名称**: "ATP1B2 as a potential biomarker for glioblastoma progression"
**作者**: Smith J, et al.
**摘要**: 研究报道ATP1B2在胶质母细胞瘤中高表达，其抗体可用于检测肿瘤组织中的蛋白水平，提示其可能作为预后标志物。
2. **文献名称**: "Role of ATP1B2 in maintaining blood-brain barrier integrity"
**作者**: Chen L, et al.
**摘要**: 通过ATP1B2抗体的免疫组化分析，发现该蛋白在血脑屏障内皮细胞中富集，可能通过调控离子转运影响屏障功能。
3. **文献名称**: "ATP1B2 antibody validation for neuronal subtype identification"
**作者**: Wang Y, et al.
**摘要**: 验证ATP1B2抗体在小鼠脑组织中的特异性，证实其可用于标记特定神经元亚群，辅助神经环路研究。
4. **文献名称**: "ATP1B2 interacts with α-subunit in cochlear hair cells"
**作者**: Kimura R, et al.
**摘要**: 利用ATP1B2抗体进行共定位实验，揭示其在耳蜗毛细胞中与钠钾泵α亚基互作，可能参与听觉信号传导。
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**注意**：以上文献为示例性质，实际研究中需通过PubMed/Google Scholar等平台以“ATP1B2 antibody”为关键词检索真实文献，并核对作者、标题及摘要准确性。
The ATP1B2 antibody targets the beta-2 subunit (β2) of the Na+/K+ ATPase, a critical ion transporter responsible for maintaining electrochemical gradients across cell membranes. This subunit, encoded by the ATP1B2 gene, plays a regulatory role in the enzyme’s activity, stability, and membrane localization by interacting with the alpha subunit. ATP1B2 is predominantly expressed in astrocytes, the inner ear, and specific brain regions, such as the cerebellum, where it supports ion homeostasis and cellular excitability.
Research on ATP1B2 has highlighted its involvement in neurological and auditory functions. Mutations or dysregulation of ATP1B2 are linked to hearing loss and neurological disorders, including epilepsy and glioblastoma. In the inner ear, ATP1B2 deficiency disrupts endolymphatic potential, impairing auditory signal transduction. In cancer, elevated ATP1B2 expression in glioblastoma correlates with tumor progression and therapy resistance.
ATP1B2 antibodies are essential tools for detecting and quantifying the β2 subunit in techniques like Western blotting, immunohistochemistry, and immunofluorescence. They enable studies on protein localization, expression patterns, and interactions in both normal and diseased tissues. These antibodies also aid in exploring molecular mechanisms underlying ion transport disorders and developing targeted therapies. Their specificity and reliability make them valuable in both basic research and clinical diagnostics.
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