| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | AAG; MDG; ADPG; APNG; Mid1; anpg; PIG11; PIG16; CRA36.1 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MPG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于MPG抗体的参考文献示例，内容基于假设性研究概括：
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1. **"Development of a Monoclonal Antibody Targeting Human MPG for DNA Repair Studies"**
*作者：Smith J, et al. (2020)*
摘要：本研究报道了一种新型小鼠源单克隆抗体的开发，该抗体特异性识别人源MPG蛋白。通过免疫印迹和免疫荧光验证，证明其在检测多种癌细胞系中MPG表达水平的可靠性，为DNA碱基切除修复机制研究提供工具。
2. **"MPG Overexpression in Colorectal Cancer: Correlation with Chemotherapy Resistance"**
*作者：Lee S, et al. (2018)*
摘要：利用MPG抗体进行免疫组化分析，发现结直肠癌组织中MPG蛋白表达显著升高，且高表达患者对5-FU化疗敏感性降低。提示MPG或可作为预测化疗反应的生物标志物。
3. **"Altered MPG Expression in Neurodegenerative Disease Models"**
*作者：Zhang Y, et al. (2021)*
摘要：通过Western blot和脑组织切片染色，发现阿尔茨海默病模型小鼠的神经元中MPG蛋白水平异常升高。研究表明，MPG介导的异常DNA修复可能导致神经元基因组不稳定，为神经退行机制提供新视角。
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注：以上文献为示例性内容，实际引用需以真实发表的论文为准。建议通过PubMed或Web of Science以“MPG antibody”或“N-methylpurine DNA glycosylase”为关键词检索最新研究。
MPG (N-Methylpurine-DNA Glycosylase), also known as AAG (alkyladenine DNA glycosylase), is a DNA repair enzyme critical for maintaining genomic stability. It initiates the base excision repair (BER) pathway by recognizing and excising damaged or aberrant DNA bases, including alkylated (e.g., 3-methyladenine, 7-methylguanine) and oxidized purines. This repair mechanism is essential for counteracting mutagenic and cytotoxic effects caused by endogenous metabolic byproducts, environmental toxins, or chemotherapeutic agents. MPG's role in DNA repair has linked it to cancer biology, as dysregulation or mutations in MPG may influence cancer susceptibility, therapeutic resistance, or response to DNA-damaging treatments.
MPG antibodies are tools developed to study the expression, localization, and function of this enzyme in biological systems. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to quantify MPG levels in tissues or cell lines, particularly in cancer research. Studies have explored MPG's dual role—while its repair activity protects against carcinogenesis, overexpression in tumors may enhance repair of chemotherapy-induced DNA damage, contributing to drug resistance. Additionally, MPG polymorphisms are investigated for associations with disease risk. Research utilizing MPG antibodies continues to clarify its therapeutic potential, either as a biomarker for treatment stratification or a target to sensitize cancer cells to genotoxic therapies.
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