| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AIP; AKIP; MRP-S38 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AURKAIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AURKAIP1抗体的3篇假设性参考文献示例，供参考：
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1. **文献名称**: "AURKAIP1 regulates mitotic progression through Aurora A kinase interaction"
**作者**: Takahashi et al.
**摘要**: 本研究利用AURKAIP1特异性抗体进行免疫荧光染色，发现AURKAIP1通过结合Aurora A激酶调控中心体成熟及纺锤体组装。抗体验证显示其在HeLa细胞中特异性识别内源性AURKAIP1蛋白。
2. **文献名称**: "AURKAIP1 overexpression correlates with poor prognosis in hepatocellular carcinoma"
**作者**: Chen & Wang
**摘要**: 通过AURKAIP1抗体对肝癌组织进行免疫组化分析，发现AURKAIP1高表达与患者生存率下降显著相关，提示其作为潜在肿瘤标志物的价值。抗体特异性通过siRNA敲低实验验证。
3. **文献名称**: "AURKAIP1 modulates mitochondrial autophagy under oxidative stress"
**作者**: Rodriguez et al.
**摘要**: 研究采用AURKAIP1抗体进行Western blot和共聚焦显微镜分析，证实AURKAIP1在氧化应激下介导线粒体自噬，其缺失导致细胞凋亡增加。抗体特异性通过KO细胞系对照确认。
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注：以上为模拟示例，实际文献需通过PubMed/Google Scholar等平台以关键词"AURKAIP1 antibody"或"anti-AURKAIP1"检索。建议结合研究场景补充实验细节(如抗体货号、应用方法)。
The AURKAIP1 antibody is a research tool designed to detect Aurora Kinase A Interacting Protein 1 (AURKAIP1), a conserved mitochondrial protein implicated in cell cycle regulation and mitochondrial function. AURKAIP1. also known as antisense RNA to AURKA, interacts with Aurora Kinase A (AURKA), a key serine/threonine kinase involved in mitotic progression, centrosome maturation, and spindle assembly. While AURKA is overexpressed in various cancers and linked to genomic instability, AURKAIP1 is thought to modulate its activity or stability, potentially acting as a regulatory factor. Studies suggest AURKAIP1 localizes to mitochondria and may play a role in maintaining mitochondrial integrity during stress, though its precise molecular mechanisms remain under investigation.
This antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study AURKAIP1 expression, subcellular localization, and interaction networks. Researchers employ it to explore AURKAIP1's involvement in diseases such as cancer, neurodevelopmental disorders, or conditions tied to mitochondrial dysfunction. Its specificity is typically validated using knockout controls or siRNA-mediated knockdown. Commercial AURKAIP1 antibodies are available from multiple suppliers, often raised in hosts like rabbits or mice, with validation data provided for specific applications. Proper experimental controls are essential due to potential cross-reactivity with homologous proteins or splice variants.
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