| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CST4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CST4抗体的3篇参考文献示例(内容为模拟，仅供参考)：
1. **"CST4 as a novel diagnostic biomarker for gastric cancer: Validation via monoclonal antibody-based ELISA"**
*作者：Li X, et al.*
*摘要：研究通过开发CST4特异性单克隆抗体，建立ELISA检测方法，证实血清CST4水平在胃癌患者中显著升高，可作为潜在的非侵入性诊断标志物。*
2. **"CST4 antibody-targeted imaging in colorectal cancer: Preclinical study using a murine model"**
*作者：Wang Y, et al.*
*摘要：利用CST4抗体标记的荧光探针在小鼠结直肠癌模型中实现肿瘤特异性成像，证明其在高表达CST4的肿瘤中具有靶向性和应用潜力。*
3. **"The role of CST4 in pancreatic ductal adenocarcinoma and its therapeutic targeting with humanized antibodies"**
*作者：Chen H, et al.*
*摘要：探讨CST4在胰腺癌中的促侵袭作用，并开发人源化CST4抗体，实验显示其可抑制肿瘤细胞迁移和裸鼠移植瘤生长。*
如需具体文献，建议通过PubMed或Google Scholar以关键词“CST4 antibody”“Cystatin-SN(CST4别名)”等检索最新研究。
CST4 antibody is a research tool designed to target cystatin-S (CST4), a member of the cystatin superfamily of cysteine protease inhibitors. Cystatin-S is primarily secreted by salivary and lacrimal glands, playing roles in maintaining oral health, regulating inflammatory responses, and modulating enzymatic activity in biological fluids. The CST4 gene encodes a 14-16 kDa protein that binds to and inhibits cathepsins, enzymes involved in protein degradation, immune regulation, and tissue remodeling. Dysregulation of CST4 has been implicated in conditions like Sjögren’s syndrome, periodontal disease, and certain cancers.
CST4 antibodies are typically produced in hosts like rabbits or mice using recombinant CST4 proteins or synthetic peptides. They enable detection of endogenous CST4 in immunoassays (e.g., Western blot, ELISA, immunohistochemistry) and are valuable for studying its expression patterns, interactions, and functional roles. Some studies explore CST4 as a potential biomarker for tumor progression or autoimmune disorders due to its altered secretion in pathological states. Commercial CST4 antibodies often undergo validation for specificity, sensitivity, and cross-reactivity across species (human, mouse, rat). Researchers utilize these antibodies to investigate CST4’s involvement in protease balance, mucosal immunity, and disease mechanisms, supporting both basic research and diagnostic applications.
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