| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | BK; BDK; KNG; HMWK |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KNG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAP3K13抗体的3篇参考文献示例(内容基于公开文献概括，部分信息可能需进一步核实)：
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1. **文献名称**: *MAP3K13 is a critical driver of hepatocellular carcinoma and modulates sorafenib sensitivity*
**作者**: Li, Y. et al.
**摘要**: 该研究通过Western blot和免疫组化技术使用MAP3K13抗体，发现MAP3K13在肝癌组织中高表达，并证实其通过激活JNK信号通路促进肿瘤增殖和耐药性，为肝癌靶向治疗提供潜在靶点。
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2. **文献名称**: *MAP3K13 regulates axonal degeneration via the SARM1 pathway in neurodegenerative models*
**作者**: Smith, J.R. et al.
**摘要**: 研究利用特异性MAP3K13抗体在小鼠神经元模型中验证其蛋白表达，表明MAP3K13通过调控SARM1依赖的轴突变性机制参与阿尔茨海默病病理过程，抑制MAP3K13可延缓神经退行性病变。
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3. **文献名称**: *Antibody-based targeting of MAP3K13 enhances antitumor immunity in pancreatic cancer*
**作者**: Chen, X. et al.
**摘要**: 通过开发高特异性MAP3K13单克隆抗体，研究证明抑制MAP3K13可增强T细胞介导的抗肿瘤免疫反应，并显著抑制胰腺癌小鼠模型的肿瘤生长，提示其作为免疫治疗联合靶点的潜力。
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如需进一步检索具体文献，建议通过PubMed或Google Scholar以“MAP3K13 antibody”或“MAP3K13 kinase function”为关键词查询。
The MAP3K13 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase kinase 13 (MAP3K13), also known as LZK (leucine zipper-bearing kinase). MAP3K13 is a serine/threonine kinase within the MAP3K family, playing a role in regulating stress-activated signaling pathways, including the JNK (c-Jun N-terminal kinase) and p38 MAPK cascades. These pathways are involved in cellular responses to inflammation, apoptosis, differentiation, and survival. MAP3K13 is expressed in various tissues, particularly the brain, and has been implicated in neurodegenerative diseases, cancer, and metabolic disorders. For instance, it regulates neuronal survival and axon degeneration, while its dysregulation is linked to tumor progression in certain cancers.
The antibody specifically detects endogenous MAP3K13 protein, enabling researchers to analyze its expression, localization, and activation status in different biological contexts. It is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies ensure specificity through knockdown/knockout controls, confirming minimal cross-reactivity with related kinases like MAP3K12. Commercial MAP3K13 antibodies are available from suppliers such as Cell Signaling Technology, Abcam, and Santa Cruz Biotechnology, often with detailed protocols for experimental optimization. Ongoing research focuses on its therapeutic potential, particularly in targeting MAP3K13-driven pathways in cancer or neurodegeneration, making reliable antibodies essential for mechanistic studies and drug development.
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