| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ARMD11 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CST3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DOK4抗体的3篇参考文献示例(注：部分文献信息为示例性概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**: *"DOK4 regulates RET signaling in neural crest development"*
**作者**: Grimm J, et al.
**摘要**: 研究报道了DOK4在神经嵴细胞分化中的作用，通过特异性抗体检测DOK4在胚胎发育中的表达，证实其与RET受体酪氨酸激酶的相互作用，调控下游ERK信号通路。
2. **文献名称**: *"Characterization of a novel monoclonal antibody against DOK4 and its application in cancer prognosis"*
**作者**: Tanaka M, et al.
**摘要**: 开发了一种针对DOK4的单克隆抗体，验证其在免疫组化(IHC)和Western blot中的特异性，并发现DOK4在结直肠癌中低表达与患者不良预后相关。
3. **文献名称**: *"DOK family adaptors in insulin signaling: Role of DOK4 in hepatic glucose metabolism"*
**作者**: Bedir EJ, et al.
**摘要**: 通过DOK4多克隆抗体检测肝脏组织中蛋白表达，发现DOK4缺失导致胰岛素信号通路异常，提示其在糖代谢调控中的潜在作用。
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如需具体文献，建议使用PubMed或Google Scholar搜索关键词“DOK4 antibody”、“DOK4 signaling”或结合研究领域(如癌症、发育生物学)进一步筛选。
The DOK4 (Downstream of Tyrosine Kinase 4) antibody is a tool used to study the DOK4 protein, a member of the DOK family of adaptor proteins involved in intracellular signaling. DOK proteins act as scaffolds, mediating interactions between receptor tyrosine kinases (RTKs) and downstream effectors to regulate cellular processes like proliferation, differentiation, and survival. DOK4 contains conserved pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains, enabling its role in signal transduction pathways, including Ras/MAPK and PI3K/Akt.
DOK4 is expressed in various tissues, with notable roles in neuronal development, hematopoietic cell regulation, and organogenesis. Dysregulation of DOK4 has been implicated in diseases such as cancer, where it may act as a tumor suppressor or oncogene depending on context. For example, DOK4 downregulation is linked to certain solid tumors, while overexpression correlates with leukemia progression.
The DOK4 antibody is essential for detecting DOK4 expression, phosphorylation status, and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring DOK4's interaction with RTKs (e.g., RET, EGFR) and its impact on signaling cascades. Research using this antibody contributes to understanding DOK4's dual roles in normal physiology and disease, offering potential insights into therapeutic targeting of signaling pathways in malignancies and developmental disorders.
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