| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IAP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ALPI |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ALPI抗体的3篇参考文献示例(注：以下内容为虚构，仅用于示例格式)：
1. **文献名称**：*Monoclonal Antibody Targeting Intestinal Alkaline Phosphatase (ALPI) Attenuates Inflammation in Experimental Colitis*
**作者**：Zhang Y, et al.
**摘要**：研究开发了一种靶向ALPI的单克隆抗体，通过中和ALPI活性减轻小鼠结肠炎模型的炎症反应，表明ALPI抗体在肠道炎症治疗中的潜力。
2. **文献名称**：*Autoantibodies Against ALPI as a Biomarker in Celiac Disease: A Serological Study*
**作者**：Müller S, et al.
**摘要**：该文献发现乳糜泻患者血清中存在抗ALPI自身抗体，其水平与肠道损伤程度相关，提示ALPI抗体可能作为疾病诊断的辅助标志物。
3. **文献名称**：*Structural Characterization of ALPI-Specific Antibodies for Therapeutic Applications*
**作者**：Tanaka K, et al.
**摘要**：通过X射线晶体学解析了ALPI与特异性抗体的结合表位，为开发基于抗体的ALPI靶向疗法(如代谢性疾病)提供了结构基础。
如需真实文献，建议在PubMed或Google Scholar以“intestinal alkaline phosphatase antibody”或“ALPI immunology”为关键词检索。
**Background of ALPI Antibodies**
Alkaline phosphatase, intestinal (ALPI), also known as intestinal alkaline phosphatase (IAP), is a member of the alkaline phosphatase enzyme family predominantly expressed in the enterocytes of the small intestine. It plays critical roles in gut homeostasis, including detoxification of bacterial lipopolysaccharides (LPS), regulation of intestinal inflammation, and maintenance of the gut barrier. Structurally, ALPI is a membrane-bound glycoprotein anchored via a glycosylphosphatidylinositol (GPI) moiety, encoded by the *ALPI* gene in humans.
ALPI antibodies are immunological tools developed to detect and quantify ALPI expression in research and diagnostics. These antibodies, often monoclonal or polyclonal, are utilized in techniques like ELISA, Western blotting, and immunohistochemistry to study ALPI's tissue distribution, expression changes in diseases (e.g., inflammatory bowel disease, obesity), or its role in gut microbiota interactions. Dysregulation of ALPI has been linked to metabolic disorders, sepsis, and gut dysbiosis, making it a biomarker of interest. Additionally, therapeutic strategies targeting ALPI, such as recombinant enzyme supplementation, are being explored for treating endotoxemia or metabolic syndromes. ALPI antibodies thus serve as vital reagents in both mechanistic studies and translational research aimed at understanding and modulating intestinal health.
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