| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HEL-S-182mP |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GNMT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于GNMT(Glycine N-methyltransferase)抗体的模拟参考文献示例，供参考。建议通过学术数据库(如PubMed、Google Scholar)检索以获取真实文献：
---
1. **文献名称**: *Development and Validation of a Polyclonal Antibody for Detecting Glycine N-Methyltransferase in Hepatic Tissues*
**作者**: Chen Y, et al.
**摘要**: 研究开发了一种高特异性的GNMT多克隆抗体，用于检测肝组织中GNMT蛋白的表达水平，并验证其在非酒精性脂肪性肝病(NAFLD)模型中的表达下调，提示GNMT缺失可能与代谢紊乱相关。
2. **文献名称**: *Autoantibodies Against GNMT as a Novel Biomarker in Hepatocellular Carcinoma*
**作者**: Huang L, et al.
**摘要**: 报道在肝癌患者血清中发现GNMT自身抗体的存在，其水平与肿瘤进展呈负相关，提示GNMT可能具有抑癌功能，自身抗体或可作为早期诊断标志物。
3. **文献名称**: *GNMT-Specific Monoclonal Antibody Reveals Its Protective Role in Acute Liver Injury*
**作者**: Wang X, et al.
**摘要**: 通过单克隆抗体技术揭示GNMT在小鼠急性肝损伤模型中的保护作用，证明其通过调节甲基供体代谢减轻氧化应激和炎症反应。
4. **文献名称**: *Epigenetic Regulation of GNMT by DNA Methylation: Insights from Antibody-Based Chromatin Immunoprecipitation*
**作者**: Kim S, et al.
**摘要**: 利用GNMT抗体进行染色质免疫沉淀(ChIP)，发现GNMT基因启动子区的DNA甲基化异常与其在肝硬化中的沉默相关，为表观遗传调控提供证据。
---
**注**：以上为模拟生成的文献条目，实际引用时请核实真实来源。建议检索关键词如“GNMT antibody”、“Glycine N-methyltransferase biomarker”等获取权威研究。
**Background of GNMT Antibodies**
Glycine N-methyltransferase (GNMT) is a metabolic enzyme primarily expressed in the liver, playing a critical role in regulating methionine and folate metabolism. It catalyzes the methylation of glycine using *S*-adenosylmethionine (SAMe), influencing cellular methylation potential and maintaining homeostasis of one-carbon units. Dysregulation of GNMT has been linked to liver diseases, metabolic disorders, and cancers, particularly hepatocellular carcinoma (HCC).
GNMT antibodies are essential tools for studying this enzyme’s expression, localization, and function in both normal and pathological contexts. These antibodies enable detection of GNMT protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to explore GNMT’s role in detoxification, its tumor-suppressive properties, and its interaction with pathways involved in oxidative stress and apoptosis.
The development of specific and high-affinity GNMT antibodies has advanced diagnostic and therapeutic research. For instance, reduced GNMT expression is a biomarker for HCC progression, making these antibodies valuable in cancer studies. Additionally, they aid in understanding metabolic syndromes, such as hyperhomocysteinemia and diabetes, where GNMT activity is often altered. Ongoing research continues to highlight GNMT’s multifaceted roles, underpinning the importance of reliable antibodies for mechanistic and clinical investigations.
×
