The ARL6IP1 (ADP-ribosylation factor-like 6 interacting protein 1) antibody is a tool used to detect and study the ARL6IP1 protein, which plays diverse roles in cellular processes. ARL6IP1. also known as JWA or PRAF3. is an endoplasmic reticulum (ER)-associated transmembrane protein implicated in membrane trafficking, ER stress response, and apoptosis regulation. It interacts with ARL6 and other proteins to influence vesicular transport and cell survival pathways. Research links ARL6IP1 to neurological disorders, including hereditary spastic paraplegia (HSP), as mutations in ARL6IP1 disrupt ER morphology and axonal transport. It also exhibits context-dependent roles in cancer, acting as either a tumor suppressor or promoter depending on the cellular environment. The ARL6IP1 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions in disease models. Its validation often includes testing in knockout controls or overexpression systems to ensure specificity. By enabling precise detection, this antibody supports studies on ARL6IP1’s molecular mechanisms in neurodegeneration, oncogenesis, and therapeutic resistance, contributing to potential diagnostic or therapeutic advancements.
