| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SCAND4; HUCEP-4; dJ874C20.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PGBD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PGBD1抗体的示例参考文献(注：以下为虚构示例，实际文献请通过学术数据库检索)：
1. **文献名称**：*PGBD1 Antibody Characterization and Its Role in DNA Transposition*
**作者**：Smith J, et al.
**摘要**：本研究开发并验证了一种高特异性PGBD1抗体，通过免疫印迹和免疫荧光证实其在人类细胞系中的表达定位，并发现PGBD1可能通过DNA转座机制参与基因组稳定性调控。
2. **文献名称**：*Development of a Monoclonal Antibody Targeting PGBD1 for Cancer Research*
**作者**：Li X, et al.
**摘要**：报道了一种新型PGBD1单克隆抗体的制备，验证其在乳腺癌组织中的高表达，并证明其可用于临床样本的免疫组化检测，提示PGBD1可能与肿瘤发生相关。
3. **文献名称**：*PGBD1 Expression Analysis in Neurological Disorders Using a Novel Polyclonal Antibody*
**作者**：Garcia R, et al.
**摘要**：通过构建PGBD1多克隆抗体，分析了阿尔茨海默病模型中PGBD1的蛋白表达变化，发现其表达水平与神经退行性病变进程相关。
4. **文献名称**：*Structural Insights into PGBD1 Function Through Antibody-Mediated Inhibition*
**作者**：Chen H, et al.
**摘要**：利用PGBD1抗体阻断实验，揭示了PGBD1蛋白的催化结构域功能，证明其在细胞分化过程中调控特定基因簇的活性。
建议通过PubMed或Google Scholar检索真实文献(关键词：PGBD1 antibody, PiggyBac transposase)。
The PGBD1 (PiggyBac Transposable Element Derived 1) antibody is a research tool used to detect the PGBD1 protein, a member of the piggyBac transposase-derived protein family. PGBD1 shares structural homology with transposases, enzymes that mediate DNA recombination and genome rearrangement. While its exact biological function remains under investigation, studies suggest roles in transcriptional regulation, chromatin remodeling, and potential involvement in neural development and cancer. PGBD1 is expressed in various tissues, with elevated levels observed in certain tumors, implying a possible link to oncogenesis.
Antibodies targeting PGBD1 are typically developed in hosts like rabbits or mice using immunogenic peptide sequences or recombinant protein fragments. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PGBD1 expression, localization, and interactions. Validation often includes testing in knockout cell lines or tissues to confirm specificity.
Research utilizing PGBD1 antibodies has explored its association with diseases, including neurodevelopmental disorders and malignancies, though mechanistic insights remain limited. Ongoing studies aim to clarify its role in DNA repair, epigenetic regulation, and cellular differentiation. As a relatively undercharacterized protein, PGBD1 antibodies are critical for unraveling its biological significance and potential therapeutic relevance.
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