Rabbit Polyclonal SPATA16 Antibody

The SPATA16 (spermatogenesis-associated protein 16) antibody is a tool used to study the role of SPATA16. a protein predominantly expressed in the testis and linked to male germ cell development. SPATA16. encoded by the *SPATA16* gene, is implicated in spermatogenesis, particularly during spermatid elongation and acrosome formation. Research suggests it interacts with other proteins involved in sperm head shaping and flagellum formation. Antibodies targeting SPATA16 are utilized in techniques like Western blot, immunohistochemistry (IHC), or immunofluorescence (IF) to investigate its expression patterns, subcellular localization, and potential dysregulation in infertility cases. Studies in animal models (e.g., mice) indicate that SPATA16 deficiency leads to abnormal sperm morphology, reduced motility, and infertility, highlighting its functional importance. Clinically, SPATA16 mutations or altered expression have been associated with human globozoospermia, a rare condition characterized by round-headed sperm and impaired fertility. The antibody aids in exploring SPATA16's molecular mechanisms, including its interaction with cytoskeletal components or acrosomal enzymes. Most SPATA16 antibodies are produced using recombinant protein fragments as immunogens, often in rabbit or mouse hosts, and validated for specificity in relevant tissues. Its applications extend to both basic reproductive biology research and diagnostic investigations of male infertility, offering insights into potential therapeutic targets or biomarkers.