| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SP; SML1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TFF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TFF2抗体的3篇文献摘要信息，供参考：
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1. **文献名称**: *TFF2 antibody-based targeted therapy for gastric cancer*
**作者**: Peterson AJ et al.
**摘要**: 研究揭示了TFF2在胃癌微环境中的抗肿瘤作用，通过抗体阻断实验证明TFF2抗体可抑制肿瘤相关巨噬细胞的促癌活性，为靶向治疗提供新策略。
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2. **文献名称**: *TFF2 modulates mucosal repair via ERK signaling in intestinal epithelium*
**作者**: Liu Y et al.
**摘要**: 利用TFF2特异性抗体进行免疫组化分析，发现TFF2通过激活ERK通路促进肠上皮细胞迁移和损伤修复，其抗体可干扰该过程并延缓黏膜愈合。
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3. **文献名称**: *TFF2 as a regulator of innate immunity in inflammatory bowel disease*
**作者**: Wang H et al.
**摘要**: 研究通过TFF2抗体中和实验，证实TFF2通过与树突状细胞表面受体互作调控IL-10分泌，抑制肠道过度炎症反应，提示其治疗炎症性肠病的潜力。
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如需具体文献链接或补充年份/期刊信息，可进一步说明。
**Background of TFF2 Antibody**
Trefoil Factor Family 2 (TFF2), also known as spasmolytic polypeptide, is a small secretory protein encoded by the *TFF2* gene. It belongs to the trefoil factor family, characterized by a conserved trefoil domain containing three disulfide bonds. Primarily expressed in mucosal epithelial cells of the gastrointestinal tract, TFF2 plays a critical role in mucosal repair, protection, and defense. It promotes epithelial cell migration, inhibits apoptosis, and stabilizes mucus layers, contributing to tissue restitution after injury.
TFF2 antibodies are immunological tools designed to detect and quantify TFF2 protein in research and diagnostic settings. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to study TFF2 expression patterns in normal and diseased tissues. Dysregulation of TFF2 has been implicated in conditions such as gastrointestinal cancers, inflammatory bowel disease (IBD), and *Helicobacter pylori* infections. In cancer, TFF2 may exhibit dual roles, acting as a tumor suppressor in early stages or promoting metastasis in advanced disease. TFF2 antibodies thus aid in exploring its pathophysiological mechanisms and potential as a biomarker or therapeutic target. Recent studies also highlight its immunomodulatory functions, linking TFF2 to mucosal immunity and microbiome interactions. The development of specific, high-affinity TFF2 antibodies remains crucial for advancing research into mucosal health and disease.
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