| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ADSF, RSTN, XCP1, FIZZ3, RETN1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RETN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RETN(抵抗素)抗体的3篇代表性文献摘要(注：内容为示例性虚构，仅供参考)：
1. **《抵抗素抗体在肥胖相关炎症中的调控作用》**
- 作者：Smith A, et al. (2018)
- 摘要：本研究通过在小鼠模型中注射RETN特异性中和抗体，证实其能显著降低脂肪组织炎症因子水平，并改善胰岛素敏感性，提示RETN抗体在代谢性疾病治疗中的潜在价值。
2. **《新型高灵敏度RETN ELISA检测方法的开发与应用》**
- 作者：Zhang Y, et al. (2020)
- 摘要：研究团队开发了一种基于单克隆RETN抗体的ELISA检测技术，可精准量化人血清中低浓度抵抗素水平，为临床糖尿病和心血管疾病的风险评估提供了新工具。
3. **《抵抗素与抗体复合物的结构解析及其功能研究》**
- 作者：Brown K, et al. (2021)
- 摘要：通过X射线晶体学揭示了RETN蛋白与其单克隆抗体的结合表位，阐明了抗体中和抵抗素促炎活性的分子机制，为靶向药物设计提供了结构基础。
(注：如需真实文献，建议通过PubMed或Google Scholar以“Resistin antibody”为关键词检索近年研究。)
The RETN antibody targets resistin, a hormone encoded by the *RETN* gene, primarily associated with metabolic regulation and inflammation. Resistin, initially identified in rodents as an adipokine secreted by adipose tissue, was linked to insulin resistance and type 2 diabetes. However, its role in humans differs; human resistin is predominantly produced by immune cells (e.g., macrophages) and epithelial cells, influencing pro-inflammatory pathways and contributing to conditions like atherosclerosis, obesity, and autoimmune diseases. Structurally, resistin is a cysteine-rich protein forming multimers, with roles in modulating glucose metabolism, immune responses, and cellular signaling via receptors such as Toll-like receptor 4 (TLR4) and adenylyl cyclase-associated protein 1 (CAP1).
RETN antibodies are critical tools for detecting resistin in research and diagnostics. They enable quantification of resistin levels in serum or tissues using techniques like ELISA, Western blot, or immunohistochemistry, aiding studies on its pathophysiological roles. Commercial RETN antibodies are often validated for specificity across species (human, mouse, rat) and applications. Despite progress, debates persist about resistin's mechanistic contributions to metabolic syndromes, underscoring the need for reliable antibodies to clarify its dual role as a metabolic and inflammatory mediator. These reagents remain pivotal in exploring resistin as a therapeutic target or biomarker for metabolic and inflammatory diseases.
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