Rabbit Polyclonal PRL Antibody

Prolactin (PRL) antibodies are essential tools for detecting and quantifying prolactin, a peptide hormone primarily associated with lactation, mammary gland development, and reproductive functions. Produced by lactotroph cells in the anterior pituitary gland, PRL also plays roles in immune regulation, metabolism, and behavior. PRL antibodies, typically polyclonal or monoclonal, are designed to bind specifically to PRL or its receptors (PRLR), enabling applications in research, diagnostics, and therapeutics. In research, these antibodies facilitate the study of PRL signaling pathways, gene expression, and hormone-receptor interactions using techniques like ELISA, Western blot, and immunohistochemistry. Clinically, they aid in diagnosing hyperprolactinemia, pituitary adenomas, and reproductive disorders. PRL immunoassays often rely on antibody pairs for sandwich ELISA to ensure high sensitivity and specificity. Cross-reactivity with PRL variants (e.g., glycosylated or cleaved forms) or homologs in different species (human, rodent) must be validated to avoid false results. PRL antibodies also contribute to cancer research, as aberrant PRL/PRLR signaling is linked to breast and prostate cancers. Their development involves immunizing hosts with full-length PRL, fragments, or synthetic peptides, followed by purification and validation. Robust PRL antibodies are critical for understanding PRL’s diverse physiological roles and its implications in disease.