| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PRMT7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRMT7抗体的参考文献示例(内容基于领域内典型研究方向，具体文献需通过学术数据库查询确认)：
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1. **文献名称**: *PRMT7 regulates breast cancer cell proliferation and invasion through histone H3 methylation*
**作者**: Zhao, Y. et al.
**摘要**: 本研究利用PRMT7特异性抗体进行Western blot和免疫荧光分析，发现PRMT7通过催化组蛋白H3的精氨酸甲基化调控乳腺癌细胞增殖和转移，抑制PRMT7可降低肿瘤侵袭性。
2. **文献名称**: *PRMT7 interacts with SMAD2/3 to modulate TGF-β signaling in stem cell differentiation*
**作者**: Gupta, R. et al.
**摘要**: 通过免疫共沉淀(Co-IP)和PRMT7抗体的应用，揭示PRMT7与SMAD2/3蛋白相互作用，影响TGF-β信号通路，从而调控间充质干细胞向成骨细胞分化。
3. **文献名称**: *PRMT7 deficiency alters DNA damage response via impaired H4R3 methylation*
**作者**: Park, J.H. et al.
**摘要**: 研究采用PRMT7敲除模型及抗体检测，发现PRMT7缺失导致组蛋白H4R3甲基化水平下降，削弱细胞对DNA损伤的修复能力，提示其在基因组稳定性中的关键作用。
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**注**：以上为示例性内容，实际文献需通过PubMed、Web of Science等平台检索关键词“PRMT7 antibody”或“PRMT7 function”获取。建议优先选择近五年内发表于*Cell*、*Nature Communications*或*Nucleic Acids Research*等期刊的研究。
PRMT7 (Protein Arginine Methyltransferase 7) is a member of the PRMT enzyme family responsible for post-translational arginine methylation, a key epigenetic modification regulating gene expression, DNA repair, and cellular signaling. Unlike other PRMTs, PRMT7 primarily catalyzes monomethylation of arginine residues and exhibits unique structural features, including a duplicated methyltransferase domain, which may contribute to its substrate specificity. It plays critical roles in diverse biological processes, such as chromatin remodeling, stem cell differentiation, and stress response. Dysregulation of PRMT7 has been linked to developmental disorders, cancer progression, and metabolic diseases.
PRMT7 antibodies are essential tools for studying its expression, localization, and function in cellular and disease contexts. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate PRMT7's interaction partners and methylation targets. Due to structural similarities among PRMT family members, high-quality PRMT7 antibodies must be rigorously validated for specificity to avoid cross-reactivity. Recent studies employing PRMT7 antibodies have highlighted its role in modulating splicing factors, maintaining genomic stability, and influencing immune responses. Challenges in antibody development include its low cellular abundance and tissue-specific expression patterns. Reliable PRMT7 antibodies continue to advance research into its therapeutic potential and mechanistic contributions to human pathologies.
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