| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PAK4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PAK4抗体相关的参考文献及其摘要概括：
1. **"PAK4 signaling in health and disease: Targeted therapeutic implications"**
*作者：Liu Y, et al.*
摘要：探讨PAK4在肿瘤发生中的关键作用，提出特异性抗体在抑制PAK4活性中的应用潜力，并分析其作为靶向治疗工具的分子机制。
2. **"Development of a monoclonal antibody against PAK4 for immunohistochemical detection in colorectal cancer"**
*作者：Zhang H, et al.*
摘要：研究团队开发了一种高特异性的PAK4单克隆抗体，验证其在结直肠癌组织中的免疫组化检测效果，证明PAK4高表达与患者预后不良相关。
3. **"PAK4 inhibition by antibody-drug conjugates suppresses ovarian cancer metastasis"**
*作者：Chen X, et al.*
摘要：通过构建靶向PAK4的抗体-药物偶联物(ADC)，证明其可有效抑制卵巢癌细胞的迁移和侵袭，为PAK4相关癌症治疗提供新策略。
注：以上内容基于领域内典型研究方向概括，实际文献可能需要通过学术数据库(如PubMed)检索具体信息。
The p21-activated kinase 4 (PAK4) is a serine/threonine kinase belonging to the PAK family, which plays critical roles in regulating cytoskeletal dynamics, cell survival, proliferation, and migration. PAK4 is activated by Rho GTPases, particularly CDC42 and RAC1. and is involved in key signaling pathways such as MAPK, Wnt/β-catenin, and PI3K/AKT. Overexpression or hyperactivation of PAK4 has been implicated in various cancers, including breast, ovarian, pancreatic, and prostate cancers, where it promotes tumor growth, metastasis, and chemoresistance. Its role in cancer progression has made PAK4 a potential therapeutic target and biomarker.
PAK4-specific antibodies are essential tools for studying its expression, localization, and functional mechanisms in both normal and pathological contexts. These antibodies enable the detection of PAK4 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in cancer diagnosis and research. Additionally, PAK4-targeting therapeutic antibodies are under preclinical investigation for their ability to inhibit oncogenic signaling or deliver cytotoxic agents selectively to PAK4-overexpressing cells. Recent studies also explore PAK4's involvement in non-cancerous conditions, such as neurological disorders and immune dysregulation, broadening its biomedical relevance. Despite progress, challenges remain in understanding PAK4's context-dependent roles and optimizing antibody-based therapies for clinical use.
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