| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human OAS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OAS2抗体的3-4条参考文献示例(内容基于学术背景合理虚构，仅供参考)：
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1. **标题**: *Autoantibodies against OAS2 in systemic lupus erythematosus: A novel biomarker for disease activity*
**作者**: Li, X., et al.
**摘要**: 本研究首次报道了系统性红斑狼疮(SLE)患者血清中抗OAS2抗体的存在，发现其水平与疾病活动指数(SLEDAI)显著相关，提示OAS2抗体可能作为SLE的新型生物标志物。
2. **标题**: *OAS2 antibody-based detection of viral infection-induced interferon response*
**作者**: Tanaka, K., & Yamamoto, M.
**摘要**: 通过开发高特异性OAS2抗体，研究团队建立了定量检测OAS2蛋白的方法，证实其在HCV感染患者中表达上调，且与干扰素通路激活程度正相关。
3. **标题**: *Role of OAS2 in COVID-19 severity and antibody-mediated neutralization assays*
**作者**: Smith, R., et al.
**摘要**: 分析COVID-19患者样本发现，OAS2表达水平与重症风险相关。利用OAS2单克隆抗体进行功能抑制实验，揭示了其在限制病毒复制中的关键作用。
4. **标题**: *Commercial OAS2 antibodies vary in specificity: Implications for research reproducibility*
**作者**: Garcia, S., et al.
**摘要**: 系统性评估了市售OAS2抗体的特异性，发现部分抗体存在交叉反应性，强调验证抗体质量对研究结果可靠性的重要性，并提出了标准化检测方案。
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注：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文。
OAS2 (2'-5'-oligoadenylate synthetase 2) is a key enzyme in the innate immune response, part of the OAS family encoded by interferon-stimulated genes. It catalyzes the synthesis of 2'-5'-linked oligoadenylates upon detecting double-stranded RNA, a hallmark of viral infection. These molecules activate RNase L, which degrades viral and cellular RNA to inhibit viral replication. OAS2 antibodies are tools used to study the expression, localization, and functional roles of OAS2 in antiviral defense and disease contexts.
Research links OAS2 to autoimmune disorders (e.g., multiple sclerosis, type 1 diabetes) and cancers, where dysregulation may influence pathogenesis. In COVID-19. OAS2 expression correlates with disease severity, highlighting its role in SARS-CoV-2 response. Antibodies against OAS2 enable detection via techniques like Western blot, immunohistochemistry, or flow cytometry, aiding mechanistic studies. They also help explore genetic variants (e.g., SNPs) affecting OAS2 activity and disease susceptibility. Commercially available OAS2 antibodies vary in specificity, requiring validation for cross-reactivity with other OAS family members (OAS1. OAS3. OASL). As a potential biomarker or therapeutic target, OAS2 remains central to understanding interferon-mediated immunity and virus-host interactions.
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