| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MM28, MMP25, MMP-28, EPILYSIN |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MMP28 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP28抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*Matrix metalloproteinase 28 regulates lung carcinogenesis and the cross-talk between macrophages and cancer cells through the EGFR signaling pathway*
**作者**：Wang, Y. et al.
**摘要**：该研究通过免疫组化分析(使用特异性MMP28抗体)揭示了MMP28在肺癌微环境中的作用，发现其通过调控巨噬细胞与癌细胞的相互作用促进肿瘤进展，并涉及EGFR信号通路。
2. **文献名称**：*Epilysin (MMP-28) restrains the macrophage inflammatory response*
**作者**：Manicone, S. et al.
**摘要**：研究者利用重组MMP28蛋白生成多克隆抗体，通过Western blot和免疫荧光技术证明MMP28在巨噬细胞中具有抑制炎症反应的功能，为靶向免疫调节提供依据。
3. **文献名称**：*MMP28 is overexpressed in prostate cancer and promotes tumor invasion and progression*
**作者**：Li, J. et al.
**摘要**：该团队开发了一种单克隆MMP28抗体，用于检测前列腺癌组织中MMP28的高表达，并证实其通过增强细胞侵袭能力促进肿瘤转移。
(注：以上文献信息为模拟示例，实际引用时需核对原文。)
Matrix Metalloproteinase-28 (MMP28), also known as epilysin, is a member of the MMP family of zinc-dependent endopeptidases involved in extracellular matrix (ECM) remodeling, tissue repair, and immune regulation. Unlike many MMPs, MMP28 is expressed in normal tissues, including skin, lungs, and testes, and is implicated in both physiological processes (e.g., epithelial homeostasis) and pathological conditions like fibrosis, cancer, and inflammation. Its unique structure, featuring a furin-like prodomain, allows intracellular activation, distinguishing it from other MMPs requiring extracellular proteolytic cleavage.
MMP28 antibodies are essential tools for detecting and studying the protein's expression, localization, and function. These antibodies, often polyclonal or monoclonal, target specific epitopes within MMP28's catalytic or hemopexin domains. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate MMP28's role in diseases. For example, studies using MMP28 antibodies have linked its overexpression to tumor progression in certain cancers and its dysregulation to fibrotic lung diseases. Validated antibodies with high specificity are critical, as cross-reactivity with other MMPs can complicate interpretation. Ongoing research aims to clarify MMP28's dual roles in tissue repair versus pathological remodeling, highlighting the antibody's importance in mechanistic and therapeutic exploration.
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