| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Proto-oncogene serine/threonine-protein kinase mos, Oocyte maturation factor mos, Proto-oncogene c-Mos, Mos |
| Entrez GeneID | 17451 |
| WB Predicted band size | 37.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse, Rat |
| Immunogen | This Mouse Mos antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-329 amino acids from the C-terminal region of mouse Mos. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MMP15抗体的3篇参考文献示例(注：以下为模拟内容，实际文献需通过学术数据库检索确认)：
1. **"MMP15 promotes hepatocellular carcinoma progression via enhancing immunosuppressive activity of tumor microenvironment"**
*作者：Li X, et al. (2021)*
**摘要**：研究利用MMP15抗体检测肝癌组织中MMP15的表达，发现其高表达与免疫抑制微环境相关，可能通过调控T细胞功能促进肿瘤进展。
2. **"MT2-MMP (MMP15) in cranial neural crest cell migration during mouse embryogenesis"**
*作者：Shimizu-Nishikawa Y, et al. (2018)*
**摘要**：通过MMP15抗体的免疫荧光染色，揭示MMP15在小鼠胚胎颅神经嵴细胞迁移中的作用，表明其参与细胞外基质重塑。
3. **"Development and validation of a novel MMP15 monoclonal antibody for colorectal cancer diagnosis"**
*作者：Wang H, et al. (2016)*
**摘要**：研究报道了一种新型MMP15单克隆抗体的开发，验证了其在结直肠癌组织中的高特异性，并探讨其作为诊断标志物的潜力。
建议通过 **PubMed** 或 **Web of Science** 输入关键词“MMP15 antibody”或“MT2-MMP antibody”获取真实文献数据。
**Background of MMP15 Antibody**
Matrix Metalloproteinase 15 (MMP15), also known as membrane-type MMP-2 (MT2-MMP), is a member of the MMP family, which plays critical roles in extracellular matrix (ECM) remodeling, cell migration, and tissue repair. As a membrane-anchored protease, MMP15 contains a catalytic domain, a transmembrane region, and a cytoplasmic tail, enabling localized proteolytic activity at the cell surface. It activates pro-MMP2. facilitating ECM degradation, and processes substrates like collagen, laminin, and adhesion molecules, influencing cellular signaling and microenvironment interactions.
MMP15 is implicated in physiological processes such as embryogenesis, angiogenesis, and wound healing, but its dysregulation is linked to pathological conditions, including cancer progression, metastasis, and inflammatory diseases. Overexpression of MMP15 in tumors correlates with enhanced invasion, angiogenesis, and poor prognosis, making it a potential therapeutic target.
MMP15 antibodies are essential tools for detecting and quantifying MMP15 expression in research. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its localization, regulation, and function in disease models. These antibodies aid in exploring MMP15's mechanistic roles and evaluating its diagnostic or prognostic value in cancer and other disorders. Developing specific and sensitive MMP15 antibodies remains crucial for advancing research into targeted therapies and understanding MMP-related pathologies.
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