| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 94 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TMPRSS7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMPRSS7抗体的3篇参考文献摘要(注：TMPRSS7研究较少，部分文献可能侧重功能而非抗体开发，以下为模拟示例)：
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1. **"TMPRSS7 as a novel therapeutic target in colorectal cancer: Antibody-based inhibition suppresses tumor progression"**
*Authors: Lee H, Kim J, Park S.*
摘要：本研究开发了一种靶向TMPRSS7的单克隆抗体，证实其通过抑制TMPRSS7的蛋白酶活性，阻断结肠癌细胞侵袭和迁移，并在小鼠模型中显著抑制肿瘤转移。
2. **"Characterization of TMPRSS7 protease activity and its role in iron metabolism"**
*Authors: Rossi E, Beguinot F, De Falco S.*
摘要：通过免疫沉淀和Western blot分析，利用特异性TMPRSS7抗体揭示了该蛋白酶在调节细胞铁转运蛋白降解中的作用，为遗传性铁过载疾病提供新机制解释。
3. **"A pan-cancer analysis of TMPRSS family members: Expression profiling and prognostic implications"**
*Authors: Zhang Y, Chen L, Wang X.*
摘要：基于多种TMPRSS家族抗体(含TMPRSS7)的免疫组化分析，发现TMPRSS7在乳腺癌和肺癌中高表达，并与患者生存率负相关，提示其作为预后标志物的潜力。
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**备注**：由于TMPRSS7研究相对较少，实际文献可能更侧重于其功能或与其他TMPRSS家族蛋白(如TMPRSS2)的交叉研究。建议通过PubMed或Google Scholar以“TMPRSS7 antibody”或“TMPRSS7 inhibitor”为关键词筛选最新论文。
The TMPRSS7 (Transmembrane Serine Protease 7) antibody is a research tool designed to detect and study the TMPRSS7 protein, a member of the type II transmembrane serine protease (TTSP) family. TMPRSS7. also known as matriptase-2. is encoded by the *TMPRSS6* gene in humans, though nomenclature inconsistencies exist in older literature. This enzyme is characterized by an N-terminal transmembrane domain, a stem region with multiple domains (e.g., LDL receptor class A, scavenger receptor cysteine-rich), and a C-terminal serine protease catalytic domain. It plays a critical role in iron homeostasis by regulating hepcidin expression through cleavage of the iron-regulatory protein hemojuvelin. Dysregulation of TMPRSS7 is linked to iron-refractory iron-deficiency anemia (IRIDA) and certain cancers.
Antibodies targeting TMPRSS7 enable researchers to investigate its expression, localization, and function in tissues and cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Due to structural similarities among TTSP family members, antibody specificity is a key challenge, requiring rigorous validation using knockout controls. Commercial TMPRSS7 antibodies are typically raised against epitopes in the extracellular or catalytic domains. Recent studies explore its potential as a therapeutic target or biomarker in cancer and metabolic disorders, driving demand for reliable detection tools. However, limited data on TMPRSS7’s full physiological roles highlight the need for further research using these antibodies.
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