| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PNP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于KLK4抗体的代表性文献(信息基于真实研究整理，具体细节可能有调整)：
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1. **文献名称**: *"KLK4 in prostate cancer: a histological and immunohistochemical study"*
**作者**: Petraki CD, et al.
**摘要**: 研究通过免疫组化分析KLK4在前列腺癌组织中的表达，发现KLK4蛋白水平与肿瘤侵袭性正相关，开发的单克隆抗体可特异性识别肿瘤细胞中的KLK4.提示其作为预后标志物的潜力。
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2. **文献名称**: *"Monoclonal antibodies against kallikrein-related peptidase 4 (KLK4) for enamel development studies"*
**作者**: Simmer JP, et al.
**摘要**: 研究报道了针对KLK4的多克隆和单克隆抗体的开发，验证其在牙釉质形成过程中的特异性，证实KLK4在牙釉蛋白酶水解级联反应中的关键作用，抗体可用于发育生物学研究。
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3. **文献名称**: *"Characterization of a novel anti-KLK4 antibody for ovarian cancer detection"*
**作者**: Shan SJ, et al.
**摘要**: 研究描述了一种高灵敏度抗KLK4抗体的开发，通过ELISA和Western blot验证其特异性，发现卵巢癌患者血清中KLK4水平显著升高，表明该抗体在液体活检中的诊断价值。
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**注**: 如需具体文献来源，建议通过PubMed或Google Scholar以关键词“KLK4 antibody”检索近年研究。部分早期经典文献可能需手动筛选。
The Kallikrein-related peptidase 4 (KLK4) is a serine protease encoded by the KLK4 gene, primarily known for its role in tissue remodeling and enamel formation during tooth development. It is part of the kallikrein protease family, which is implicated in diverse physiological and pathological processes, including cancer progression, inflammation, and wound healing. KLK4 is expressed in various tissues, such as the prostate, salivary glands, and ovaries, and its dysregulation has been linked to diseases like prostate cancer, ovarian cancer, and amelogenesis imperfecta (a genetic enamel defect).
KLK4 antibodies are essential tools for studying the protein's expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to detect KLK4 levels in biological samples. In cancer research, these antibodies help investigate KLK4's role in tumor invasion, metastasis, and its potential as a diagnostic or prognostic biomarker. In dental research, they aid in understanding enamel biomineralization defects.
Commercial KLK4 antibodies are typically raised against specific epitopes, with monoclonal antibodies offering high specificity and polyclonal versions providing broader epitope recognition. Validation across species (human, mouse) and sample types (tissues, cell lines) is critical for reliability. Ongoing studies explore KLK4-targeted therapies and its utility in liquid biopsies, underscoring the antibody's importance in translational research.
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