| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | CSN5, JAB1, SGN5, MOV-34 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COPS5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COPS5抗体的3篇代表性文献，按研究内容和应用方向概括：
1. **文献名称**: *"COPS5 promotes tumor progression by downregulating TGF-β signaling in hepatocellular carcinoma"*
**作者**: Li Y, et al.
**摘要**: 该研究利用COPS5抗体通过Western blot和免疫组化技术，证实COPS5在肝癌组织中高表达，并通过抑制TGF-β信号通路促进肿瘤生长和转移。
2. **文献名称**: *"The COP9 signalosome subunit 5 (COPS5) regulates cell cycle progression via modulating p53 stability"*
**作者**: Wang H, et al.
**摘要**: 研究通过免疫沉淀(IP)和COPS5抗体验证COPS5与p53的相互作用，发现其通过泛素化途径调控p53降解，影响细胞周期进程和DNA损伤修复。
3. **文献名称**: *"COPS5 as a novel therapeutic target for triple-negative breast cancer"*
**作者**: Zhang R, et al.
**摘要**: 利用COPS5抗体在乳腺癌模型中发现COPS5过表达与患者预后不良相关，靶向抑制COPS5可显著降低肿瘤细胞增殖和侵袭能力。
这些文献均通过COPS5抗体进行蛋白表达分析或功能研究，涵盖其在癌症进展、细胞周期调控及靶向治疗中的关键作用。
**Background of COPS5 Antibody**
The COPS5 antibody is a tool used to detect and study the COP9 signalosome subunit 5 (COPS5), a critical component of the COP9 signalosome (CSN) complex. The CSN is an evolutionarily conserved multiprotein complex involved in regulating ubiquitin-proteasome-mediated protein degradation, primarily by modulating cullin-RING ubiquitin ligases (CRLs). COPS5. also known as CSN5 or Jab1. plays a central role in this process through its isopeptidase activity, which removes the ubiquitin-like protein NEDD8 from cullins, thereby regulating CRL activity and substrate specificity.
Beyond its role in protein degradation, COPS5 participates in diverse cellular processes, including cell cycle progression, DNA damage response, and signaling pathways such as NF-κB and HIF-1α. Dysregulation of COPS5 has been implicated in cancer, inflammation, and neurodegenerative diseases, with studies linking its overexpression to tumor progression and poor prognosis.
COPS5 antibodies are essential for investigating its expression, localization, and interactions in various biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore COPS5’s molecular mechanisms and therapeutic potential. Available as monoclonal or polyclonal variants, these antibodies enable researchers to dissect COPS5’s dual roles as a regulator of cellular homeostasis and a contributor to disease pathogenesis.
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