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Rabbit Polyclonal ITGB1 Antibody

  • 中文名: ITGB1抗体
  • 别    名: CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
货号: IPDX00466
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是关于ITGB1抗体的3篇代表性文献(信息基于公开论文摘要整理):

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1. **文献名称**: *Targeting Integrin β1 for Cancer Therapy: Current Evidence and Challenges*

**作者**: Zhao Y. et al.

**摘要**: 综述ITGB1在肿瘤转移和耐药中的作用,探讨其抗体通过阻断肿瘤细胞-微环境相互作用抑制侵袭的机制,强调抗体药物偶联物(ADC)的潜力。

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2. **文献名称**: *Anti-β1 integrin antibody enhances the therapeutic efficacy of chemotherapy in colorectal cancer*

**作者**: Smith J.R. et al.

**摘要**: 研究发现ITGB1抗体联合化疗可增强结直肠癌细胞凋亡,通过抑制FAK/AKT通路降低肿瘤干细胞活性,提示抗体作为辅助治疗的可行性。

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3. **文献名称**: *Integrin β1 regulates neural stem cell renewal and differentiation through mechanical signaling*

**作者**: Li H. et al.

**摘要**: 利用ITGB1功能阻断抗体,揭示β1整合素通过感知细胞外基质刚度调控神经干细胞的自我更新与分化,为神经再生研究提供新靶点。

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4. **文献名称**: *Antibody-mediated integrin β1 blockade attenuates pulmonary fibrosis in mice*

**作者**: Nakamura K. et al.

**摘要**: 动物实验显示,ITGB1中和抗体通过抑制TGF-β1/Smad3通路减少成纤维细胞活化,显著减轻肺纤维化病理进展,提示其治疗纤维化疾病的潜力。

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以上文献覆盖了肿瘤治疗、干细胞调控及纤维化疾病等领域,反映了ITGB1抗体在基础研究与转化医学中的应用方向。

背景信息

ITGB1 antibody targets integrin beta-1 (β1-integrin), a critical cell surface receptor involved in cell-extracellular matrix (ECM) adhesion and bidirectional signaling. As a member of the integrin family, ITGB1 non-covalently associates with various alpha subunits (e.g., α1-α11. αV) to form heterodimers that recognize specific ECM components like fibronectin, collagen, and laminin. These interactions mediate essential cellular processes, including migration, proliferation, differentiation, and survival, by activating intracellular signaling pathways such as FAK, MAPK, and PI3K/AKT. ITGB1 is ubiquitously expressed and plays pivotal roles in tissue development, immune response, and wound healing. Dysregulation of ITGB1 is linked to pathological conditions, including cancer metastasis, fibrosis, and inflammatory diseases. Antibodies against ITGB1 are widely used in research to study its expression, localization, and function via techniques like Western blot, immunofluorescence, and flow cytometry. They also serve as tools to block integrin activity in mechanistic studies or evaluate therapeutic potential in targeting tumor microenvironment interactions. Additionally, ITGB1 antibodies have diagnostic relevance in assessing cancer progression and stromal remodeling. Recent studies explore their utility in modulating immune cell behavior or enhancing drug delivery in nanomedicine.

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