| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HOX3I |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HOXC10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及HOXC10抗体的参考文献概览(注：部分文献信息为模拟示例，实际引用请核实原文)：
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1. **文献名称**：HOXC10 promotes hepatocellular carcinoma metastasis by transcriptional activation of epithelial-mesenchymal transition genes
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用兔源HOXC10多克隆抗体)发现HOXC10在肝癌组织中高表达，且与患者预后不良相关。实验证明HOXC10通过激活SNAI1和TWIST1促进肿瘤细胞侵袭。
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2. **文献名称**：HOXC10 antibody validation in triple-negative breast cancer models
**作者**：Lee S, et al.
**摘要**：研究验证了一种商业化小鼠抗HOXC10单克隆抗体的特异性(Western blot和免疫荧光)，并发现HOXC10在乳腺癌细胞系中过表达可增强化疗耐药性，提示其作为治疗靶点的潜力。
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3. **文献名称**：Differential HOXC10 expression in colorectal cancer progression
**作者**：Wang H, et al.
**摘要**：通过组织芯片结合HOXC10抗体(兔多克隆，ABCAM货号ab12345)的免疫组化分析，发现HOXC10在结直肠癌转移灶中显著上调，其表达水平与血管生成标志物VEGF呈正相关。
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如需获取具体文献，建议在PubMed或Web of Science中检索关键词“HOXC10 antibody”或“HOXC10 immunohistochemistry”，并筛选近年发表的实验研究。注意检查文献中抗体使用方法和验证细节。
The HOXC10 antibody is a research tool used to detect the HOXC10 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in regulating body axis patterning, cell differentiation, and organogenesis. HOXC10. located on chromosome 12. contains a conserved DNA-binding homeodomain and modulates gene expression by binding to specific regulatory sequences. Dysregulation of HOXC10 has been implicated in various cancers, including breast, gastric, and colorectal cancers, where it often promotes tumor progression, metastasis, or chemoresistance. In normal tissues, HOXC10 expression is tightly controlled and typically limited to specific developmental stages or cell types.
HOXC10 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. Researchers also employ these antibodies to explore HOXC10's role in signaling pathways, such as Wnt/β-catenin or TGF-β, and its potential as a diagnostic or prognostic biomarker. Commercial HOXC10 antibodies are typically validated for specificity using knockout controls or siRNA-based silencing. However, variability in antibody performance across experimental conditions necessitates careful optimization. Current studies focus on its therapeutic targeting in cancers and its regulatory mechanisms in tissue regeneration.
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