| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HOX1, HOX1B, HOX1.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HOXA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXA6抗体的3篇假设性文献示例，结构参考真实研究场景：
1. **文献名称**：**"HOXA6 expression in colorectal cancer: A potential prognostic biomarker"**
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化(使用兔源HOXA6多克隆抗体)分析了结肠癌组织中HOXA6蛋白的表达水平，发现HOXA6在肿瘤组织中的显著下调与患者生存期缩短相关，提示其可能作为预后标志物。
2. **文献名称**：**"Development and validation of a monoclonal antibody specific for human HOXA6 protein"**
**作者**：Zhang L, et al.
**摘要**：研究团队成功制备并验证了一种高特异性HOXA6单克隆抗体，通过Western blot和免疫荧光证实其可特异性识别HOXA6蛋白，并应用于胚胎小鼠模型中HOXA6的时空表达图谱分析。
3. **文献名称**：**"HOXA6 regulates limb development through mesenchymal cell differentiation"**
**作者**：Garcia R, et al.
**摘要**：利用HOXA6抗体进行小鼠胚胎原位杂交及免疫染色，揭示了HOXA6在肢体间充质细胞分化中的关键作用，其表达异常导致骨骼发育缺陷。
4. **文献名称**：**"HOXA6 as a novel biomarker in neuroblastoma progression"**
**作者**：Chen H, et al.
**摘要**：通过抗HOXA6抗体的流式细胞术和免疫组化分析，发现HOXA6在侵袭性神经母细胞瘤中高表达，可能通过调控细胞迁移通路促进肿瘤转移。
(注：上述文献为示例，实际引用需查询真实数据库如PubMed或Google Scholar。)
The HOXA6 antibody is a tool used to detect and study the HOXA6 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body axis patterning and organogenesis. HOXA6. located on chromosome 7p15.2. plays roles in hematopoietic, skeletal, and reproductive system development. Dysregulation of HOXA6 has been linked to cancers, including leukemia, colorectal cancer, and lung adenocarcinoma, where it may act as an oncogene or tumor suppressor depending on context.
HOXA6 antibodies are typically monoclonal or polyclonal, generated in hosts like rabbits or mice, and validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies help researchers analyze HOXA6 expression patterns, subcellular localization (primarily nuclear), and interactions with regulatory proteins.
Studies using HOXA6 antibodies have revealed its involvement in cell differentiation, proliferation, and apoptosis. For instance, reduced HOXA6 expression correlates with poor prognosis in certain cancers, suggesting its potential as a biomarker. Additionally, HOXA6 interacts with signaling pathways like Wnt and TGF-β, offering insights into therapeutic targets. The antibody remains vital for exploring HOXA6's dual roles in development and disease.
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