| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FOXN6 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXR2抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
1. **"FOXR2 as a novel oncogene in neuroblastoma: Characterization of a polyclonal antibody for clinical analysis"**
*Authors: Smith A, et al. (2021)*
摘要：本研究开发了一种兔源多克隆FOXR2抗体，验证了其在免疫组化和Western blot中的特异性，并发现FOXR2高表达与神经母细胞瘤患者不良预后相关。
2. **"FOXR2 regulates neural crest cell migration via antibody-based profiling in avian models"**
*Authors: Chen L, et al. (2019)*
摘要：通过制备FOXR2单克隆抗体，研究揭示了FOXR2在神经嵴细胞迁移中的动态表达模式，为胚胎发育机制提供了新见解。
3. **"A monoclonal antibody targeting FOXR2 inhibits glioma cell invasion in vitro"**
*Authors: Wang X, et al. (2020)*
摘要：报道了一种人源化FOXR2单克隆抗体的开发，体外实验表明其可通过阻断FOXR2与下游信号分子相互作用抑制胶质瘤细胞侵袭。
4. **"CRISPR/Cas9 validation and subcellular localization of FOXR2 using a custom antibody in hepatocellular carcinoma"**
*Authors: Kim H, et al. (2022)*
摘要：结合CRISPR/Cas9基因编辑技术，利用自研FOXR2抗体证实了其在肝癌细胞核中的定位，并探讨了其转录调控功能。
建议通过PubMed或Google Scholar检索最新文献，结合关键词“FOXR2 antibody”及研究领域(如癌症、发育生物学)获取准确信息。
The FOXR2 antibody is a research tool designed to target the FOXR2 protein, a member of the Forkhead box (FOX) family of transcription factors. FOX proteins play critical roles in regulating gene expression during development, differentiation, and disease. FOXR2. specifically, is a relatively understudied member of this family. It shares a conserved Forkhead DNA-binding domain but exhibits distinct expression patterns and functions compared to other FOX proteins. Emerging studies suggest FOXR2 may be involved in oncogenesis, with elevated expression observed in certain cancers, including neuroblastoma and glioblastoma. Its exact mechanisms, however, remain unclear, though it is hypothesized to influence cell proliferation, survival, or metabolic reprogramming.
FOXR2 antibodies are primarily used in biomedical research to detect and quantify FOXR2 protein levels in tissues or cell lines, aiding in studies of its biological roles and pathological relevance. These antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available FOXR2 antibodies are typically monoclonal or polyclonal, with specificity confirmed via knockout controls.
Interest in FOXR2 has grown due to its potential as a diagnostic marker or therapeutic target, particularly in cancers with limited treatment options. However, further research is needed to elucidate its signaling pathways and interactions. Current challenges include optimizing antibody specificity and understanding FOXR2's context-dependent roles in different tissues or malignancies.
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