| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DYR; DHFRP1 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DHFR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOSL2抗体的3篇文献概览(基于公开信息整理，非实时数据库查询结果)：
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1. **文献名称**：*FOSL2 promotes EMT via regulation of SLUG in ovarian cancer*
**作者**：Li Y, et al.
**摘要**：研究利用FOSL2抗体检测卵巢癌细胞中FOSL2蛋白表达，发现FOSL2通过调控SLUG基因促进上皮间质转化(EMT)，增强癌细胞侵袭和转移能力。
2. **文献名称**：*FOSL2 as a novel prognostic biomarker in hepatocellular carcinoma*
**作者**：Wang X, et al.
**摘要**：通过免疫组化(使用FOSL2抗体)分析肝癌组织样本，发现FOSL2高表达与患者不良预后相关，提示其可作为肝癌潜在生物标志物。
3. **文献名称**：*FOSL2 interacts with c-JUN to drive AP-1-mediated transcriptional activation in breast cancer*
**作者**：Chen H, et al.
**摘要**：研究通过ChIP实验(使用FOSL2抗体)证实FOSL2与c-JUN形成复合物，激活AP-1依赖性转录通路，促进乳腺癌细胞增殖和耐药性。
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如需具体文献来源或更新数据，建议通过PubMed、Google Scholar等平台检索标题或作者名获取原文。
The FOSL2 antibody is a tool used to detect FOS-like antigen 2 (FOSL2), a member of the FOS family of transcription factors. FOSL2. also known as Fra-2. forms part of the AP-1 (Activator Protein 1) complex by dimerizing with JUN proteins, regulating gene expression in response to stress, cytokines, and growth signals. It plays roles in cell proliferation, differentiation, and apoptosis, and is implicated in cancer, immune responses, and tissue remodeling.
FOSL2 antibodies are typically generated in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. These antibodies enable the study of FOSL2 expression, localization, and function through techniques like Western blotting (detecting ~40 kDa protein), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is validated via knockout controls or siRNA knockdown.
Research using FOSL2 antibodies highlights its dual roles: it promotes tumor progression in certain cancers (e.g., breast, lung) but acts as a tumor suppressor in others. Dysregulation of FOSL2 is linked to fibrosis, autoimmune diseases, and metabolic disorders. The antibody is crucial for exploring FOSL2's regulatory mechanisms, including post-translational modifications (e.g., phosphorylation) and interactions with signaling pathways like MAPK. Its versatility makes it essential for both basic research and clinical biomarker studies.
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