| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GDH; GDH1; GLUD |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GLUD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FABP4抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *Fatty Acid-Binding Protein 4 (FABP4) Suppresses Melanoma Growth by Coordinating Immune Evasion*
**作者**: Goto, M., et al.
**摘要**: 本研究利用FABP4抗体通过免疫组化分析黑色素瘤组织，发现FABP4通过调控肿瘤微环境中的免疫抑制信号(如PD-L1)抑制肿瘤生长。抗体阻断实验表明FABP4在促进T细胞衰竭中的作用，提示其作为免疫治疗靶点的潜力。
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2. **文献名称**: *FABP4 Deficiency in Macrophages Exacerbates Atherosclerosis Through Activation of the NLRP3 Inflammasome*
**作者**: Xu, H., et al.
**摘要**: 研究通过FABP4抗体检测巨噬细胞中FABP4的表达，发现FABP4缺失导致炎症小体NLRP3过度活化，加剧动脉粥样硬化斑块形成。抗体介导的蛋白定位证实FABP4在调控脂质代谢与炎症反应中的关键作用。
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3. **文献名称**: *Circulating FABP4 as a Biomarker for Early Diabetic Nephropathy: Validation by ELISA and Clinical Cohort Studies*
**作者**: Lee, C.H., et al.
**摘要**: 研究开发了一种基于FABP4抗体的高灵敏度ELISA检测方法，验证了血清FABP4水平与糖尿病肾病早期肾功能损伤的相关性。队列分析表明FABP4可作为预测疾病进展的生物标志物。
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每项研究均利用FABP4抗体进行蛋白检测或功能干预，涵盖肿瘤免疫、代谢疾病及临床诊断等领域。
Fatty Acid-Binding Protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2. is a lipid chaperone protein primarily expressed in adipocytes and macrophages. It plays a critical role in lipid metabolism, inflammation, and cellular signaling by facilitating the transport of fatty acids and regulating their intracellular distribution. FABP4 is implicated in metabolic disorders such as obesity, insulin resistance, and atherosclerosis, as well as cancer progression and immune modulation. Its dysregulation is associated with pathological processes like adipose tissue dysfunction, chronic inflammation, and tumor microenvironment remodeling.
FABP4 antibodies are essential tools for detecting and quantifying this protein in research and diagnostic applications. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA) to study FABP4 expression patterns in tissues, cells, or biological fluids. These antibodies help elucidate FABP4's role in metabolic diseases, cancer metastasis, and inflammatory responses. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple epitopes, enhancing sensitivity in certain assays. Validation of FABP4 antibodies often includes knockout controls to confirm target specificity.
Recent studies highlight FABP4 as a potential therapeutic target or biomarker for metabolic syndromes and cancers, driving demand for reliable antibodies in drug development and mechanistic studies. Their applications extend to evaluating therapeutic interventions targeting FABP4 pathways in preclinical models.
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