| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24, ZIF-268 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human EGR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于EGR1抗体的参考文献及其摘要概括：
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1. **文献名称**: "Early growth response protein 1 (EGR1) is a key regulator of the hepatic lipid metabolic response to sepsis"
**作者**: Li Y, et al.
**摘要**: 该研究利用EGR1抗体通过免疫印迹和免疫组化技术，发现EGR1在脓毒症模型中调控肝脏脂质代谢的关键作用，揭示了其通过调节脂肪酸氧化基因表达影响代谢紊乱的机制。
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2. **文献名称**: "EGR1 as a transcriptional activator of matrix metalloproteinases in diabetic retinopathy"
**作者**: Wang H, et al.
**摘要**: 研究通过染色质免疫沉淀(ChIP)结合EGR1抗体，证明EGR1在糖尿病视网膜病变中激活基质金属蛋白酶(MMPs)的表达，促进血管内皮细胞异常增生和基底膜降解。
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3. **文献名称**: "Validation of a high-specificity monoclonal EGR1 antibody for neuroscience research"
**作者**: Smith TP, et al.
**摘要**: 本文验证了一种高特异性EGR1单克隆抗体在神经组织中的应用，通过免疫荧光和流式细胞术证实其在检测神经元活动依赖性EGR1表达中的可靠性，为神经科学提供重要工具。
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这些文献分别展示了EGR1抗体在代谢调控、疾病机制研究及实验工具开发中的关键应用。如需具体期刊信息或补充文献，可进一步检索PubMed或SciHub获取全文。
The EGR1 (Early Growth Response Protein 1) antibody is a crucial tool for studying the EGR1 transcription factor, which plays a pivotal role in regulating gene expression in response to extracellular signals. EGR1. encoded by the EGR1 gene, belongs to the zinc-finger transcription factor family and is rapidly induced by growth factors, stress, or cellular differentiation cues. It regulates genes involved in cell proliferation, apoptosis, and tissue remodeling.
Antibodies targeting EGR1 are widely used in research to detect and quantify EGR1 protein levels in various experimental models, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). These applications help elucidate EGR1’s role in physiological processes (e.g., neuronal development, immune response) and pathologies such as cancer, cardiovascular diseases, and neurological disorders.
EGR1 dysregulation is linked to tumor progression, fibrosis, and inflammation, making its antibody valuable in biomarker studies. Commercial EGR1 antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions) in hosts like rabbits or mice. Validation includes testing for specificity via knockout controls or siRNA knockdown.
Researchers prioritize antibodies with high specificity and low cross-reactivity to related family members (EGR2-4). As EGR1’s activity is context-dependent, its antibody serves as a key reagent in dissecting signaling pathways and transcriptional networks in health and disease.
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