关键信息
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基因名
TXNDC4
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简介
The TXNDC4 protein is critical in cellular processes, mediating thiol-dependent retention in the early secretory pathway.Its conserved CRFS motif forms mixed disulfide bonds with substrate proteins to control oxidative protein folding in the endoplasmic reticulum and maintain cellular redox balance.TXNDC4 Protein, Human (HEK293, His) is the recombinant human-derived TXNDC4 protein, expressed by HEK293 , with C-6*His labeled tag.
- 应用
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别名
Thioredoxin domain-containing protein 4; ER protein 44; KIAA0573; TXNDC4
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BS26
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表达区间
E30-D402
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氨基酸序列
EITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRD
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蛋白长度
Partial
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TXNDC4 (Thioredoxin Domain Containing 4) is a member of the thioredoxin family, which plays a crucial role in various cellular processes, including redox regulation, protein folding, and stress response. Research has increasingly focused on TXNDC4 due to its involvement in both normal physiological functions and pathological conditions, such as cancer and neurodegenerative diseases. This protein is known to modulate cellular signaling pathways by interacting with key proteins involved in oxidative stress responses. Additionally, TXNDC4's ability to maintain thiol-redox balance makes it a potential target for therapeutic interventions. The recombinant form of TXNDC4 has been utilized in various studies to elucidate its biological functions, determine its molecular interactions, and explore its potential as a biomarker for disease states. Understanding the structural and functional characteristics of TXNDC4 through recombinant techniques can provide insights into its role in cellular homeostasis and highlight its therapeutic implications. Overall, the research on TXNDC4 recombinant protein is vital for deciphering the complexities of redox biology and its ramifications in both health and disease.
