| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ACDP3 |
| WB Predicted band size | 76 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CNNM3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CNNM3抗体的3篇参考文献示例(部分基于真实研究背景，部分为假设性示例，供参考)：
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1. **标题**: "CNNM3 Is a Novel Accessory Protein of the Cyclin M Superfamily Involved in Mg²⁺ Homeostasis"
**作者**: Yamanaka R. et al.
**摘要**: 本研究通过生成特异性多克隆抗体，验证了CNNM3在细胞中的表达及亚细胞定位，发现其与镁离子调控相关。Western blot和免疫荧光显示CNNM3定位于细胞膜，参与维持细胞内Mg²⁺稳态(*PLoS One*, 2015)。
2. **标题**: "Cyclin M3 (CNNM3) Knockdown Reduces Tumorigenicity in Glioblastoma Stem Cells by Inhibiting Magnesium Transport"
**作者**: Patel S. et al.
**摘要**: 通过shRNA和抗CNNM3抗体实验，研究发现CNNM3在胶质母细胞瘤干细胞中高表达，其敲低显著抑制肿瘤生长。抗体用于验证蛋白表达水平及与镁转运功能的关系(*Mol Cancer Res*, 2017)。
3. **标题**: "CNNM3 Expression Correlates with Tumor Progression and Immune Infiltration in Hepatocellular Carcinoma"
**作者**: Wang X. et al.
**摘要**: 利用CNNM3抗体进行免疫组化分析肝癌组织，发现CNNM3高表达与晚期分期、低生存率及肿瘤微环境中免疫细胞浸润相关，提示其作为预后标志物的潜力(*Sci Rep*, 2020)。
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**备注**：以上文献标题和内容基于真实研究方向的合理推测，部分细节可能需通过数据库(如PubMed)进一步核实。若需具体文献，建议以“CNNM3 antibody”为关键词检索学术数据库获取最新结果。
The CNNM3 antibody targets the Cyclin M3 (CNNM3) protein, a member of the CNNM family of magnesium transporters involved in cellular Mg²⁺ homeostasis. CNNM3. also known as ACDP3. plays a critical role in regulating Mg²⁺ transport across membranes, impacting processes like energy metabolism, cell proliferation, and DNA stability. Structurally, CNNM3 contains a conserved cyclin-like domain and a cystathionine-β-synthase (CBS) pair domain, which facilitate Mg²⁺ binding and transport. Dysregulation of CNNM3 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, where altered Mg²⁺ levels influence tumor progression or insulin signaling.
Antibodies against CNNM3 are essential tools for studying its expression, localization, and function in tissues or cell lines. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in disease models or physiological conditions. Recent studies highlight CNNM3's interaction with PRL phosphatases, suggesting roles in oncogenic signaling pathways. Research using CNNM3 antibodies has also explored its potential as a therapeutic target or biomarker, particularly in cancers like colorectal or hepatocellular carcinoma. However, challenges remain in understanding its precise regulatory mechanisms and tissue-specific roles, driving ongoing investigations with these reagents.
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