| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CycC; SRB11; hSRB11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CCNC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CCNC(Cyclin C)抗体相关的参考文献及其摘要概括：
1. **"Cyclin C/CDK8 coordinates transcription elongation and cell cycle progression"**
*作者：Rickert et al.*
摘要：研究揭示了CCNC与CDK8复合物在调控RNA聚合酶II转录延伸中的作用，并通过抗体检测发现其在细胞周期G1/S期的动态变化，暗示其连接转录调控与细胞周期进程。
2. **"Cyclin C is a haploinsufficient tumour suppressor"**
*作者：Li et al.*
摘要：利用CCNC特异性抗体进行免疫组化分析，发现CCNC在多种癌症中表达下调，并通过小鼠模型证明其作为单倍剂量不足抑癌基因的功能，参与DNA损伤修复调控。
3. **"A CDK8-Cyclin C complex involved in extrinsic apoptosis signaling"**
*作者：Firestein et al.*
摘要：通过免疫共沉淀(Co-IP)和Western blot技术，验证CCNC-CDK8复合物在死亡受体信号通路中的调控作用，其抗体被用于检测复合物在凋亡过程中的动态组装。
4. **"Cyclin C regulates muscle stem cell quiescence and regeneration"**
*作者：Jones et al.*
摘要：研究采用CCNC抗体进行免疫荧光染色，发现其在小鼠肌肉干细胞静息状态维持中的关键作用，敲除CCNC导致干细胞过早激活及再生能力受损。
注：以上文献为示例性质，实际引用时需核对具体来源期刊及作者信息。
CCNC (Cyclin C) is a regulatory protein belonging to the cyclin family, which plays critical roles in cell cycle progression and transcriptional regulation. Unlike classical cyclins that primarily regulate cyclin-dependent kinases (CDKs) during specific cell cycle phases, Cyclin C forms a complex with CDK8 or CDK19. functioning as part of the Mediator complex—a multi-protein assembly that modulates RNA polymerase II-dependent transcription. This Cyclin C-CDK8/19 module is involved in stress response pathways, influencing gene expression in reaction to DNA damage, oxidative stress, or nutrient deprivation. Studies suggest Cyclin C also participates in apoptosis under severe cellular stress by relocating to mitochondria to initiate programmed cell death.
CCNC antibodies are essential tools for investigating these diverse roles. They enable detection of Cyclin C expression levels, subcellular localization (nuclear vs. mitochondrial), and interactions with CDK8/19 or Mediator components. Dysregulation of Cyclin C has been implicated in cancers, metabolic disorders, and neurodegenerative diseases, making its study clinically relevant. For example, reduced Cyclin C levels correlate with poor prognosis in certain tumors, while its overexpression may protect against oxidative damage. Researchers employ CCNC antibodies in techniques like Western blotting, immunofluorescence, and ChIP-seq to explore its dual functions in transcription and stress signaling. Recent interest also focuses on targeting the Cyclin C-CDK8 axis for therapeutic intervention in cancer and inflammatory diseases.
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