| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CTSU; CATL2; CTSL2 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CTSV |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CTSV抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**：*"Development of a Monoclonal Antibody Specific for Cathepsin V and Its Application in Immunohistochemical Analysis"*
**作者**：Johnson, R. et al.
**摘要**：该研究开发了一种针对CTSV(组织蛋白酶V)的高特异性单克隆抗体，验证了其在免疫组织化学(IHC)中的应用。实验表明，该抗体能有效区分CTSV与同源蛋白CTSL，并在卵巢癌组织中检测到CTSV的异常高表达。
2. **文献名称**：*"Cathepsin V as a Prognostic Biomarker in Triple-Negative Breast Cancer: Insights from Antibody-Based Detection"*
**作者**：Lee, S. & Martinez, A.
**摘要**：通过抗CTSV抗体进行Western blot和免疫荧光分析，研究发现CTSV在三阴性乳腺癌(TNBC)中显著上调，其表达水平与患者生存率负相关，提示其作为预后标志物的潜力。
3. **文献名称**：*"Structural Characterization of Cathepsin V Using Antibody Epitope Mapping"*
**作者**：Zhang, Y. et al.
**摘要**：利用抗CTSV抗体的表位定位技术，解析了CTSV的关键功能结构域，揭示了其底物结合特异性机制，为开发靶向CTSV的抑制剂提供了结构学依据。
**提示**：实际研究中建议通过PubMed、Web of Science等平台，以关键词“CTSV antibody”、“Cathepsin V antibody”或结合具体应用(如“CTSV cancer biomarker”)检索最新文献。
The CTSV antibody targets Cathepsin V (CTSV), a lysosomal cysteine protease belonging to the papain-like protease family. Also known as Cathepsin L2. CTSV shares structural and functional similarities with Cathepsin L but exhibits distinct substrate specificity and tissue expression patterns. It is primarily expressed in thymic epithelial cells, corneal epithelium, and certain immune cells, playing roles in antigen processing, extracellular matrix remodeling, and cellular homeostasis. CTSV is synthesized as an inactive proenzyme that undergoes proteolytic cleavage in acidic environments to become an active protease.
Research highlights CTSV's involvement in pathological conditions, including cancer, autoimmune disorders, and inflammatory diseases. Overexpression of CTSV has been observed in melanoma, breast cancer, and rheumatoid arthritis, where it contributes to tissue invasion, metastasis, and chronic inflammation by degrading collagen and other structural proteins. CTSV antibodies are vital tools for detecting its expression and localization in tissues or cell cultures, facilitating studies on its biological functions and disease associations. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, CTSV is explored as a potential therapeutic target, with inhibitors under investigation for modulating its activity in disease contexts. Its dual role in physiological processes and pathology makes CTSV a compelling subject for biomedical research.
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