| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BTG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于BTG1抗体的参考文献示例(内容为虚构示例，仅供参考)：
---
1. **文献名称**: "BTG1 suppresses proliferation and promotes differentiation in neuroblastoma via interaction with MYCN"
**作者**: Zhang L, et al.
**摘要**: 本研究利用BTG1抗体通过免疫共沉淀和Western blot技术，揭示了BTG1与MYCN蛋白的相互作用，抑制神经母细胞瘤细胞增殖并诱导分化，提示其作为肿瘤抑制因子的潜在机制。
2. **文献名称**: "BTG1 expression correlates with prognosis in diffuse large B-cell lymphoma"
**作者**: Wang Y, et al.
**摘要**: 通过免疫组化(使用BTG1单克隆抗体)分析弥漫大B细胞淋巴瘤组织样本，发现BTG1低表达与患者不良预后显著相关，表明其在淋巴瘤进展中的调控作用。
3. **文献名称**: "BTG1 regulates Wnt/β-catenin signaling in colorectal cancer stem cells"
**作者**: Kim S, et al.
**摘要**: 研究采用BTG1抗体进行流式细胞术和免疫荧光染色，证实BTG1通过抑制Wnt/β-catenin通路降低结直肠癌干细胞的自我更新能力，为靶向治疗提供新思路。
4. **文献名称**: "Epigenetic regulation of BTG1 in hepatocellular carcinoma"
**作者**: Chen H, et al.
**摘要**: 通过ChIP-qPCR(使用BTG1抗体)和甲基化分析，发现肝癌中BTG1启动子高甲基化导致其表达下调，恢复BTG1表达可抑制肿瘤生长。
---
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“BTG1 antibody”或“BTG1 function”，并筛选近年高被引研究。
BTG1 (B-cell translocation gene 1) is a member of the BTG/TOB family of proteins, which are involved in regulating cellular processes such as proliferation, differentiation, and apoptosis. First identified in B-cell lymphomas, BTG1 acts as a transcriptional co-regulator and may interact with proteins like the CCR4-NOT complex to influence mRNA stability and degradation. Its expression is linked to cell cycle arrest and anti-proliferative effects, suggesting a tumor-suppressive role in certain cancers.
BTG1 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect BTG1 protein levels in tissues or cultured cells. Research has shown that BTG1 downregulation correlates with poor prognosis in cancers such as B-cell malignancies and gliomas, while its role in neuronal development and regeneration is also under investigation.
Commercial BTG1 antibodies vary by host species, clonality, and epitope specificity, requiring validation for experimental conditions. Understanding BTG1's regulatory networks and disease associations continues to advance through antibody-based studies, offering insights into therapeutic targets for cancer and neurological disorders.
×
